Rivastigmine

'Rivastigmine is a reversible non-competitive inhibitor of cholinesterases. Rivastigmine is used in alzheimer''s dementia to increase brain cholinergic activity.'


Adult Dose
Dose: 1.5 mg
Single Dose: 1.5 (1.5)
Frequency: 12 hourly
Route: PO
Instructions: Dose may be increased according to the response by 1.5 mg at minimum. 2 week intervals to Max. Dose 6 mg BID.
Neonatal
Paedriatic
Dose: Not applicable in paeds
Single Dose:
Frequency:
Route:
Instructions:
Characteristics
. It is of Synthetic origin and belongs to Carbamate. It belongs to Cholinestrase inhibitor pharmacological group on the basis of mechanism of action and also classified in Cholinergic Agonist pharmacological group.The Molecular Weight of Rivastigmine is 250.30.
Contraindications
Rivastigmine is contraindicated in conditions like Hypersensitivity.
Effects
The severe or irreversible adverse effects of Rivastigmine, which give rise to further complications include Urinary tract infection, Respiratory tract infections, Psychiatric disease.The symptomatic adverse reactions produced by Rivastigmine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Fatigue, Nausea, Vomiting, Anorexia, Diarrhea, Insomnia, Abdominal pain, Sweating, Confusion, Malaise, Tremor, Asthenia, SomnolenceX, Syncope, Agitation, Increased intracranial pressure.
Indications
'Rivastigmine is primarily indicated in conditions like Alzheimer''s disease, Dementia, Mild to moderate dementia in alzheimer''s disease.'
Interactions
Rivastigmine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementChloroquineChlorprothixenetake with food ro reduce irritation.Chlortetracycline (HCl)ClindamycinColistin (Sulphate & Sulphomethate Na)GlycopyrrolateHydroxychloroquine (Sulphate)LithiumProcainamide (HCl)Propafenone (HCl)QuinidineQuinineSuxamethonium (Cl) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Caps, Soln Store Below 40°C.
Warnings
Rivastigmine should be used only if clearly needed during pregnancy. It should be used with caution in patients with asthma, seizure disorder, epilepsy, heart disease such as hypertension, bradycardia, recent myocardial infraction, thyroid disorders, intestinal disorders, ulcers, urinary problems or if have any allergy especially to bromides. Large dose by mouth should be avoided in condition where there may be increased absorption from the gastrointestinal tract. Use of rivastigmine is associated with weight loss and monitoring of patients weight during treatment is recommended.
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