Quetiapine

Quetiapine is antipsychotic drug. Quetiapine is used to treat mental disorders such as schizophrenia.


Adult Dose
Dose: 25 mg
Single Dose: 25 (25)
Frequency: 12 hourly
Route: PO
Instructions: Initially.Then 50 mg BID on day 2, 100 mg BID on day 3 then adjust to a usual range of 300-450 mg/day.
Neonatal
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
belongs to Dibenzothiazepine. It belongs to Psychotherapeutic Drugs and Antipsychotic Agent pharmacological group.The Molecular Weight of Quetiapine is 883.10.
Contraindications
Quetiapine is contraindicated in conditions like Blood dyscrasias,Bone marrow depression,Coma,CNS depression.
Effects
The severe or irreversible adverse effects of Quetiapine, which give rise to further complications include Tachycardia, Transient leucopenia, Neutropenia, Neuroleptic malignant syndrome.The symptomatic adverse reactions produced by Quetiapine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Constipation, Dry mouth, SomnolenceX, Orthostatic hypotension, Liver enzyme abnormalities.
Indications
Quetiapine is primarily indicated in conditions like Mania, Psychosis, Schizophrenia.
Interactions
Quetiapine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholcyclobenzaprine hydrochlorideAgents with anticholinergic properties (e.g., sedating antihistamines; antispasmodics; neuroleptics; phenothiazines; skeletal muscle relaxants; tricyclic antidepressants; disopyramide) may have additive effects when used in combination. paralytic ileus, hyperthermia, heat stroke, and the anticholinergic intoxication syndrome. Peripheral symptoms of intoxication commonly include mydriasis, blurred vision, flushed face, fever, dry skin and mucous membranes, tachycardia, urinary retention, and constipation. Central symptoms may include memory loss, disorientation, incoherence, hallucinations, psychosis, delirium, hyperactivity, twitching or jerking movements, stereotypy, and seizures.MajorCaution is advised when agents with anticholinergic properties are combined, particularly in the elderly and those with underlying organic brain disease, who tend to be more sensitive to the central anticholinergic effects of these drugs and in whom toxicity symptoms may be easily overlooked. Patients should be advised to notify their physician promptly if they experience potential symptoms of anticholinergic intoxication such as abdominal pain, fever, heat intolerance, blurred vision, confusion, and/or hallucinations.ErythromycinFluconazoleItraconazoleKetoconazoleMetoclopramide (HCl)Thioridazine (HCl)VORICONAZOLEVoriconazole may increase the serum concentration of quetiapine by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store Between 20°C-25°C. Protect from Sunlight and Moisture.
Warnings
Quetiapine should be used with caution in patients with any allergy (especially drug allergies), liver or heart disease, blood vessel disease, very low blood pressure, seizure disorder or brain cancer. Get up slowly, to avoid dizziness and lightheadedness when rising from a seated or lying position. Limit alcohol intake as it may aggravate side effects. Caution is advised when performing activities requiring mental alertness (e.g.driving). This drug might hinder body temperature control, it is advised not to exercise strenuously and to avoid extreme heat while using this. It should be used only when clearly needed during pregnancy. Avoid use during lactation. Caution when this drug is used in the elderly.
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