Protirelin

Protirelin is a hypothalamic releasing hormone which stimulates release of thyrotropin from anterior lobe of pituitary.It also has Prolactin releasing activity. Protirelin (Tartrate) is a . Protirelin (Tartrate) is used parentrally in the diagnosis of hypothyroidism.

Brands
PROBRIN
Adult Dose
Dose: 200 to 400 mcg
Single Dose: 300 (300)
Frequency: As recommended.
Route: IV
Instructions:
Neonatal
Dose: 0.025 mg/kg
Single Dose: 0.025 (0.025)
Frequency: As recommended.
Route: Intravenous
Instructions: Single dose
Paedriatic
Dose: 0.02 mg/kg
Single Dose: 0.02 (0.02)
Frequency: As recommended.
Route: Intra Venous
Instructions: Single Dose
Characteristics
Protirelin (Tartrate) is the derivative of Protirelin. It is of Synthetic origin and belongs to Tripeptide. It belongs to Psychotherapeutic Drugs pharmacological group.The Molecular Weight of Protirelin is 362.40.
Contraindications
Protirelin
Effects
The severe or irreversible adverse effects of Protirelin, which give rise to further complications include Convulsions, Bronchospasm.The signs and symptoms that are produced after the acute overdosage of Protirelin include Hypotension, Unconsciousness.The symptomatic adverse reactions produced by Protirelin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Facial flushing, Flushing, Hot flushes, Micturition, BP alteration, Altered pulse rate.
Indications
Protirelin is primarily indicated in conditions like Assessment of thyroid function, Coma, Diagnostic test for thyroid cancer differentiation, Graves disease, Oliguria due to renal failure, Radiological contrast agent, Unconciousness, and can also be given in adjunctive therapy as an alternative drug of choice in Neurological disorders, Spinal cord trauma, Subarachnoid haemorrhage.
Interactions
No data regarding the interactions of Protirelin was found.
Interfrence
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Store in a well closed container. Protect from Sunlight and Moisture. Inj Store at room temperature.
Warnings
Protirelin should be given with care to patients with ischaemic heart disease, obstructive airway disease or severe hypopituitarism.
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