Dose: 0.93 to 1.43 mg/kg
Single Dose: 1.2 (1.18)
Frequency: 4 hourly
Route: PO
Instructions: -

Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group

Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group

belongs to Aminopropionic Acid. It belongs to OPIATE agonist pharmacological group on the basis of mechanism of action and also classified in Analgesics and Anti-inflammatory Agents and Analgesic-Narcotic pharmacological group.The Molecular Weight of Propoxyphene is 339.50.

Propoxyphene is contraindicated in conditions like Paralytic ileus,Respiratory depression,Hypersensitivity to any component of product,Severe asthma.

The symptomatic adverse reactions produced by Propoxyphene are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Dizziness, Headache, Drowsiness, Fatigue, Restlessness, Insomnia, Confusion, Sedation, Malaise, Hypotension, Light headedness, Paradoxical effects.

Propoxyphene is primarily indicated in conditions like Pain.

Propoxyphene is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholAlprazolamCarbamazepinePropoxyphene interferes with metabolism and clearance of carbamazepine producing toxic effect like headache, dizziness, ataxia.CarbamazepineADVICE: Generally avoid. The co-administration of Propoxyphene and Carbamazepine may result in significantly elevated plasma Carbamazepine concentrations. This interaction has been reported in various case reports and studies, with increases in Carbamazepine levels by up to 6-folds and associated toxicity in some cases. The proposed mechanism is decreased clerance of Carbamazepine due to inhibition of CYP450 3A4 enzymatic activity by Propoxyphene. ClobazamInsulin GlulisinePropoxyphene, oral antidiabetic products, pramlintide, ACE inhibitors, fibrates, monoamine oxidase inhibitors, salicylates, and somatostatin analogs, may increase the blood glucose-lowering effect of insulins and therefore increase the risk of hypoglycemia.MeclofenamateThe concurrent administration of propoxyphene hydrochloride does not affect the bioavailability of meclofenamate sodium.Metoprolol (Tartrate)Propoxyphene increases the serum level of metoprolol by inhibiting CYP450 2D6 first-pass metabolism and decreasing hepatic clearence.ModerateReduce the dose of metoprolol. Closely monitor for hypotension, heart failure, brady cardia, arrythmia and mental status.Nefopam (HCl)NicotineEspecially inform your doctor if you are using this combination.OpiumOpium may have additive CNS or respiratory-depressant effects with propoxyphene.Dosage reductions may be appropriate. Patients should be monitored for potentially excessive or prolonged CNS and respiratory depression and other CNS adverse effects.PhenobarbitonePhenytoin (Na)Phenytoin (Na)PrimidoneWarfarin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Tab, Caps Store Below 40°C. Protect from Sunlight and Moisture.

Propoxyphene should be used with caution in patients with central nervous system (CNS) depression, convulsive disorder, ulcerative colitis, fever, recent gastrointestinal (GI) surgery, bradyarrhythmias, supraventricular tachycardia, pulmonary diseases. Patients should exercise caution while driving or performing tasks requiring alertness because it may produce drowsiness.