Plasma Protein Fraction

Plasma Protein Fraction is a sterile solution of selected proteins derived from the blood plasma of adult human donors. It contains protein, of which about 83-90% is albumin and the remainder is a and β globulins. Plasma Protein Fraction is used as a substitute for plasma in treating non-hemorrhagic shock and as a source of protien for intravenous nutrition.


Adult Dose
Dose: 500 ml
Single Dose: 500 (500)
Frequency: As recommended.
Route: IV-inf
Instructions: At rate not exceeding 10 ml/min.
Neonatal
Dose: 20 to 30
Single Dose: 25 (25)
Frequency: As recommended.
Route: IV Infusion
Instructions: As required
Paedriatic
Dose: 20 to 30 ml/kg
Single Dose: 25 (25)
Frequency: As recommended.
Route: IV Infusion
Instructions: Infuse at 10 ml/min.As required
Characteristics
. It is of Natural origin and belongs to Protein. It belongs to Plasma Protein Fractions and Blood Product Derivative pharmacological group.
Contraindications
Plasma Protein Fraction is contraindicated in conditions like Anaemia,Congestive heart failure,Hypersensitivity to any component of product.
Effects
The symptomatic adverse reactions produced by Plasma Protein Fraction are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Urticaria, Hypotension, Flushing, Back pain.
Indications
Plasma Protein Fraction is primarily indicated in conditions like Hypovolaemia, and can also be given in adjunctive therapy as an alternative drug of choice in Cardiac insufficiency.
Interactions
Plasma Protein Fraction is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementDoxepin (HCl) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
Rapid infusion of Plasma Protein Fraction (greater than 10mL/minute) has produced hypotension in patients undergoing surgery or in the preoperative or postoperative period. Blood pressure should be monitored during use and infusion slowed or ceased if sudden hypotension occurs. Plasma Protein Fraction does not provide coagulation factors and therefore does not correct coagulation disorders.
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