Phytomenadione

Phytomenadione or vitamin K1, is a synthetic compound that is chemically indistinguishable from naturally occurring vitamin K1. Vitamin K is found in both plant and animal sources, and is also produced by intestinal bacteria; however, vitamin K from these different sources is not identical. Phytonadione is found in plants and is the only natural vitamin K available for therapeutic use. Menaquinones (vitamin K 2) are a series of compounds that can be synthesized by bacteria. Vitamine K is an essential cofactor in the hepatic synthesis of prothrombin and other blood clotting factors. vitamin K decreases the effects of oral anticoaggulants, and is used to counteract excessive effects of these drugs.

Brands
PHYTO- K PHYTO- K VITAMIN K KONAKION-MM PHYTOMENADIONE VITAMIN K VITAMIN K
Adult Dose
Dose: 20 to 2.5 mg
Single Dose: 11 (11.25)
Frequency: As recommended.
Route: IV,IM,SC
Instructions: As Required
Neonatal
Dose: 0.3 mg/kg
Single Dose: 0.3 (0.3)
Frequency: As recommended.
Route: Intra Muscular
Instructions: Single Dose
Paedriatic
Dose: 0.3 mg/kg
Single Dose: 0.3 (0.3)
Frequency: As recommended.
Route: Intra Muscular
Instructions: Single Dose
Characteristics
belongs to Naphthalene. It belongs to Vitamin K Derivative pharmacological group.The Molecular Weight of Phytomenadione is 450.70.
Contraindications
Phytomenadione is contraindicated in conditions like Hypersensitivity to any component of product.
Effects
The signs and symptoms that are produced after the acute overdosage of Phytomenadione include Hyperbilirubinemia, Jaundice, Hemolytic anemia.The symptomatic adverse reactions produced by Phytomenadione are more or less tolerable and if they become severe, they can be treated symptomatically, these include SweatingX, Flushing, Cyanosis.
Indications
Phytomenadione is primarily indicated in conditions like Haemorrhage, Haemorrhagic disease of newborn, Hypoprothrombinemia.
Interactions
No data regarding the interactions of Phytomenadione was found.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store Below 40°C. Do not Freeze. Protect from Sunlight. Tab Store in a well closed container, Below 40°C. Protect from Sunlight.
Warnings
Phytomenadione should be used as directed during pregnancy or lactation. It should be used with caution in patients with any pre-existing blood disorders or allergy.
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