Perindopril

Perindopril is angiotensin-converting enzyme (ACE) inhibitor used in the treatment of hypertension, congestive heart failure, and various renal syndromes such as diabetic nephropathy and scleroderma. Perindopril is a prodrug, converted to an active form before exerting its effect.it has affinity for ACE and competes with angiotensin I, the natural substrate, to block its conversion to angiotensin II. Angiotensin II is a potent vasoconstrictor and a negative feedback mediator for renin activity. Thus, as a result of lower angiotensin II plasma levels, blood pressure decreases and plasma renin activity increases. Decreases in plasma angiotensin II levels reduce aldosterone secretion, with a subsequent decrease in sodium and water retention. It also dilates arterioles, thereby lowering total peripheral vascular resistance.

Brands
COVERSYL COVERSYL COVERSYL BI PRETERAX PRETERAX DOPRIL DOPRIL HARTACE HARTACE COVERSAM COVERSAM COVERSAM COVERSAM COVERSYL PLUS AMPER AMPER CONEXT PERINDOPINE PERINDOPINE HARTACE PLUS
Adult Dose
Dose: 2 mg
Single Dose: 2 (2)
Frequency: As recommended.
Route: PO
Instructions: For Congestive heart failure: Dose may be increased to 4 mg once blood pressure acceptability has been demonstrated.
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
belongs to Indole. It belongs to Angiotensin converting enzyme inhibitor-ACEI pharmacological group on the basis of mechanism of action and also classified in Antihypertensive Agents pharmacological group.The Molecular Weight of Perindopril is 368.47.
Contraindications
Perindopril is contraindicated in conditions like Aortic stenosis,Angioedema,Hypersensitivity to the drug.
Effects
The severe or irreversible adverse effects of Perindopril, which give rise to further complications include Thrombocytopenia, Leucopenia, Neutropenia, Paresthesia, Myocardial infarction.The signs and symptoms that are produced after the acute overdosage of Perindopril include Hypothermia, Circulatory arrest.The symptomatic adverse reactions produced by Perindopril are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Fatigue, Nausea, Diarrhea, Constipation, Tinnitus, Abdominal pain, Rashes, Epigastric discomfort, Dyspepsia, Cough, Asthenia, Dry cough, Taste disturbances, Mood swings.
Indications
Perindopril is primarily indicated in conditions like Congestive heart failure, Heart failure, Heart failure (adjunct), Hypertension, Myocardial infarction.
Interactions
No data regarding the interactions of Perindopril was found.
Interfrence
Abnormal renal function testSerum bilirubin raisedSerum creatinin raised
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store Below 25°C.
Warnings
Regular renal function tests advised during prolonged treatment with Perindopril Erbumine. Care with initial dose due to postural hypotension. Avoid perindopril in patients with reno-vascular disease or aortic stenosis. Caution in patients with history of serosal inflammatory conditions. In hypertensive patients with unilateral or bilateral renal artery stenosis, increases in blood urea nitrogen and serum creatinine may occur. Experience with ACE inhibitors suggests that these increases are usually reversible upon discontinuation of the drug. In such patients, renal function should be monitored during the first few weeks of therapy. Treatment should start under close medical supervision. Avoid use during pregnancy.
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