Pergolide

Pergolide is a synthetic ergot derivative and a dopaine agonist, directly stimulates both D1 and D2 receptors.Chemically Pergolide is 8-(methylthio)methyl]-6-propylergoline. Pergolide is used in Parkinson`s disease as an adjunct to levodopa/carbidopa, prolongs the response to Levodopa in patients with response fluctuation. The drug may also benefit patients not receiving Levodopa. It works by stimulating dopamine receptors in the brain.

Brands
CELANCE CELANCE CELANCE
Adult Dose
Dose: 50 ug
Single Dose: 50 (50)
Frequency: 12 hourly
Route: PO
Instructions: On days 2-4, then 100-200 ug daily every 3-4 days in 3 div.doses.
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions:
Characteristics
Pergolide Mesylate is the derivative of Pergolide. It is of Synthetic origin and belongs to Ergot Alkaloid. It belongs to Dopamine agonist pharmacological group on the basis of mechanism of action and also classified in Antiparkinson Agents pharmacological group.The Molecular Weight of Pergolide is 410.60.
Contraindications
Pergolide is contraindicated in conditions like Valvular heart disease,Pericarditis,Valvular heart disease,Fibrositis,Hypersensitivity to any component of product.
Effects
The severe or irreversible adverse effects of Pergolide, which give rise to further complications include Cardiac arrhythmias, Rashes, Allergic reactions, Syncope, Chest pain, Myocardial infarction.The signs and symptoms that are produced after the acute overdosage of Pergolide include Seizures, Fainting, Agitation, Nausea & vomiting, Tingling.The symptomatic adverse reactions produced by Pergolide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Dizziness, Drowsiness, Nausea, Anorexia, Diarrhea, Anxiety, Palpitation, Tremors, Constipation, Dry mouth, Confusion, Hallucination, SomnolenceX, Rhinitis, Dystonic reactions, Stomachache, Vasodilation, Loss of appetite, Stomach upset.
Indications
'Pergolide is primarily indicated in conditions like Parkinsonism, Parkinson''s disease (adjunctive with levodopa), Parkinson''s disease (monotherapy), and can also be given in adjunctive therapy as an alternative drug of choice in Hyperprolactinaemia, Tourette''s syndrome.'
Interactions
Pergolide is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementDomperidoneFluoxetine (HCl)Theoretical potential for FLUOXETINE HYDROCHLORIDE increasing the EXTRAPYRAMIDAL side effects of PERGOLIDE MESILATE. Usually no risk. Usually no action necessary.LisinoprilInfrequent reports of PERGOLIDE MESILATE increasing the HYPOTENSIVE effect of LISINOPRIL. Usually no risk. Usually no action necessary.MemantineLikely interaction of MEMANTINE increasing the DOPAMINERGIC effect of PERGOLIDE MESILATE. May need to avoid combinationMajorMetoclopramide (HCl)Octreotide (Acetate)PimozideLikely interaction of PERGOLIDE MESILATE increasing the EXTRAPYRAMIDAL side effects of PIMOZIDE. Selegiline (HCl)VORICONAZOLEVoriconazole may increase the serum concentration of pergolide likely by decreasing its metabolism. Concomitant therapy is contraindicated.Warfarin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Pergolide should be used with caution in patients with pre-existing heart disease or a history of heart arrhythmias (abnormal rhythms), hallucinations, mental confusion, difficulty in walking, allergies, kidney disease or low blood pressure. Caution should be exercised when administering pergolide mesylate to patients prone to cardiac dysrhythmias. In a study comparing pergolide mesylate and placebo, patients taking pergolide mesylate were found to have signifiscantly more episodes premature contractions (PACs) and sinus tachycardia. Patients and their families should be informed of the common adverse consequences of the use of pergolide mesylate and the risk of hypotension. Patients should be advised to notify their physician if they become pregnant or intend to become pregnant during therapy. Patients should be advised to notify their physician if they are breast feeding an infant. Liver disease may alter the response to drugs in several ways. Prescribing should be kept to a minimum in all patients with severe liver disease, especially if jaundice, ascites, or evidence of encephalopathy present. Consider dose reduction in renal failure to avoid possibility of toxicity, increased sensitivity, and side effects. Get up slowly, to avoid dizziness and lightheadedness when rising from a seated or lying position. It should be used with caution when performing tasks requiring mental alertness such as driving or using machinery. Limit alcohol use because it may intensify the drowsiness and dizziness effects of this drug. It should be used with caution during pregnancy.
Back to List

Any information that appears on this website page is provided for the purpose of general information. This website has been compiled in good faith by HMIS.Online. However, no guarantee is made as to the completeness, validity or accuracy of the information it contains.