Pentoxifylline

'Pentoxifylline is a vasodilator, used in the treatment of peripheral vascular disease like intermittant claudication, Raynaud''s syndrome. It may be useful in lowering blood sugar level, also reduces blood presure. Caution may be needed if given with antihypertensive or insulin as it may increase their effects'

Brands
AGAPURIN AGAPURIN
Adult Dose
Dose: 400 mg
Single Dose: 400 (400)
Frequency: 8 hourly
Route: PO
Instructions:
Neonatal
Dose: Safety not established
Single Dose:
Frequency:
Route:
Instructions:
Paedriatic
Dose: Safety not established
Single Dose:
Frequency:
Route:
Instructions:
Characteristics
Pentoxifylline also known as Oxpentifylline. . It is of Synthetic origin and belongs to Xanthine. It belongs to Phosphodiesterase inhibitor pharmacological group on the basis of mechanism of action and also classified in Vasodilators pharmacological group.The Molecular Weight of Pentoxifylline is 278.30. Its pKa is 0.28.
Contraindications
Pentoxifylline
Effects
The signs and symptoms that are produced after the acute overdosage of Pentoxifylline include Bradycardia, AV block.The symptomatic adverse reactions produced by Pentoxifylline are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Vomiting, Urticaria, Pruritus, GI distention.
Indications
Pentoxifylline is primarily indicated in conditions like Cerebrovascular disease, Circulatory system disease, Raynaud`s phenomenon, and can also be given in adjunctive therapy as an alternative drug of choice in Peripheral vascular disease, Venous leg ulcers.
Interactions
Pentoxifylline is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAspirinInsulin GlulisinePentoxifylline, oral antidiabetic products, pramlintide, ACE inhibitors, fibrates, monoamine oxidase inhibitors, salicylates, and somatostatin analogs, may increase the blood glucose-lowering effect of insulins and therefore increase the risk of hypoglycemia.Insulin LisproKetorolac (Tromethamine)MeloxicamTheophylline These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Urinary Estimation of Pregnanediol by Gas Chromatographic Assay.
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Give pentoxifylline with caution to patients with chronic occlusive arterial disease of limb because it can cause other arteriosclerotic disease. Monitor the systemic blood pressure (B.P) especially in patients receiving antihypertensive drugs.
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