Pefloxacin

Pefloxacin is a fluoroquinolone antibiotic with actions and uses similar to those of ciprofloxacin. Pefloxacin is used to treat a variety of bacterial infections like respiratory tract, ENT, skin, urinary tract infections etc. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the drug at regular intervals of time throughout the day and night as prescribed. Pefloxacin is important to take the drug for the full time period as prescribed. Discontinuation of the drug, may result in ineffective treatment.

Brands
KROJECT PEFLACINE PEFLACINE PEXIN PIPRO PIPRO PEFLICON ABAKTAL ABAKTAL NEOFLOX EUPHEN EUPHEN PFX PFX PEFLOX PEFOCIN NEOLOX P-FLOXIN P-FLOXIN PELOX EVEQUIN PEXACIN QUCARE OLIP OLIP GRAMOCIN PELACIN PECOCIN PEFYAN P-FAZ OLIPEX ZEFLOMED APLOX PECIN QUIX POXILEX WEBIFLOX PEPSIL OFEXIN PILOXIN PEFLOGRAY GONOCOX FLOXPE PEBACT P-LOCK PEFALO PEFLORISE PELOXIN PUPIN XOFOX TOPESTIN PEFLO P-FLOREX PEFCIN PUFOX PEFTEC PELIFE AL-BACT PEFICIN QUINORAINS P PEFRO
Adult Dose
Dose: 400 mg
Single Dose: 400 (400)
Frequency: 12 hourly
Route: IV Inf
Instructions: Over 60 min.
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
Pefloxacin Mesilate is the derivative of Pefloxacin. It is of Semi Synthetic origin and belongs to Fluoroquinolone. It belongs to DNA Gyrase inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Quinolone pharmacological group.The Molecular Weight of Pefloxacin is 465.50.
Contraindications
Pefloxacin is contraindicated in conditions like Hypersensitivity.
Effects
The symptomatic adverse reactions produced by Pefloxacin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Insomnia, GI upset, Muscle pain, Articular pain.
Indications
Pefloxacin is primarily indicated in conditions like Acne, Bacterial infections, Bronchitis, Burns, Conjuctivitis, Cystitis, Dysenteries, Folliculitis, Impetigo, Otitis media, Pneumonia, Prostatitis, Pyelonephritis, Respiratory tract infections, Sedation in intensive care, Sinusitis, Superficial infections, Surgical infections, Tonsillitis, Urethritis.
Interactions
No data regarding the interactions of Pefloxacin was found.
Interfrence
Thyroid Function Test
Risks
Drug should not be given to Paediatrics, and Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab, Inj Protect from Sunlight.
Warnings
Adjust doses in the renal and hepatic impairment. Ask patients to report any signs of depression.
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