Pantoprazole

Pantoprazole is a proton pump inhibitor and causes long lasting inhibition of gastric acid secretion and used in the treatment of peptic ulcers. Chemically Pantoprazole is identified as 5-(difluoromethoxy)-2-[[(3,4-dimethyl-2-pyridinyl) methyl] sulfinyl]-1H-benzimidazole. Pantoprazole is a novel substituted benzimidazole sulfoxide derived prodrug similar to omeprazol and lansoprazol. Pantoprazole is administered orally.


Adult Dose
Dose: 0.571 mg/kg
Single Dose: 0.57 (0.571)
Frequency: 24 hourly
Route: PO
Instructions: For 8 weeks
Neonatal
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
Pantoprazole (sodium sesquihydrate), Pantoprazole (sodium sesquihydrate) are the derivatives of Pantoprazole. It is of Synthetic origin and belongs to Benzimidazole. It belongs to H/K Atpase proton pump inhibitor pharmacological group on the basis of mechanism of action and also classified in Antacids pharmacological group.The Molecular Weight of Pantoprazole is 383.40.
Contraindications
Pantoprazole is contraindicated in conditions like Hypersensitivity.
Effects
The symptomatic adverse reactions produced by Pantoprazole are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Dizziness, Nausea, Vomiting, Anxiety, Dyspnea, Pain, Pharyngitis, Cough, Arthralgia, Rhinitis, Chest pain, Bronchitis, Backache, Urinary frequency, UTI, Hyperlipidemia, Migraine, Neck pain, Rectal disorders, Hypertonia, Sinusitis, Flu like syndrome, Hyperglycemia.
Indications
Pantoprazole is primarily indicated in conditions like Benign gastric ulcer, Duodenal ulcer, Duodenal ulcer and gastric ulcer, Duodenal ulcer associated with h. Pylori, Esophagitis, Gastro-oesophageal reflux disease, Oesophagitis, Peptic ulcer, Prophylaxis of NSAID-associated gastric or duodenal ulcer, Zollinger-ellison syndrome, and can also be given in adjunctive therapy as an alternative drug of choice in Prophylaxis of NSAID-associated gastric or duodenal ulcer.
Interactions
Pantoprazole is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAmpicillinPantoprazole may decrease the effectiveness of ampicillin.AtazanavirPantoprazole may decrease the effectiveness of Atazanavir.CeftibutenClarithromycinConcurrent use may increase the risk of Pantoprazole side effects.ClopidogrelPantoprazole may decrease the effectiveness of Clopidogrel.DabrafenibProton pump inhibitors may alter the solubility of dabrafenib and reduce its bioavailabilityDigoxinPantoprazole may increase the risk of side effects of Warfarin (Na).KetoconazolePantoprazole may decrease the effectiveness of Ketoconazole.Warfarin (Na)Pantoprazole may increase the risk of side effects of Warfarin (Na). These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Liver Function Tests
Risks
Drug should not be given to Paediatrics, and patients suffering from Kidney dysfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
Pantoprazole should be used with caution in patients with liver or kidney disease or of any drug allergy. It should be used only when clearly needed during pregnancy. Avoid use during lactation. The elderly may be especially sensitive to this drug, so use with caution.
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