ANZATAX ANZATAX ANZATAX TAXOL UNITAXEL PACLITAX PACLITAX PACLITAX EBETAXEL EBETAXEL PANATAXEL PACLITAXEL PACLITAXEL VARIFARMA INTAXEL INTAXEL INTAXEL INTAXEL METAPLAXEL METAPLAXEL PACLIXIL PACLIXIL PACLIXIL ONCOTAXEL PACLITAXFIL PACLITAXEL EBEWE PACLITAXEL EBEWE PACLITAXEL EBEWE PACLITAXEL AHP PACLIKEBIR PACLIKEBIR PACLIKEBIR

Dose: 175 mg/sq.meter
Single Dose: 320 (321)
Frequency: As recommended.
Route: IV Inf
Instructions: Over 3 hrs., repeated every 3 weeks

Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group

Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group

belongs to Benzoyl Amino Lactic Acid. It belongs to Antineoplastic Agent, Plant Derivative pharmacological group.The Molecular Weight of Paclitaxel is 853.90.

Paclitaxel is contraindicated in conditions like Neutropenia.

The severe or irreversible adverse effects of Paclitaxel, which give rise to further complications include Cardiac arrhythmias, Anemia, Bradycardia, AV-block, Neutropenia, Bone marrow depression.The symptomatic adverse reactions produced by Paclitaxel are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Diarrhea, Mucositis, Myalgia, Hypotension, Arthralgia, Thrombocytopenia, UTI, Paresthesias, Blood infection, Respiratory tract infections.

Paclitaxel is primarily indicated in conditions like Breast cancer, Ovarian cancer, Primary ovarian cancer.

Paclitaxel is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCisplatinDoxorubicin (HCl)FluorouracilKetoconazolePodophyllumThe risk of peripheral neuropathy may be increased during concurrent use of two or more agents that are associated with this adverse effect. In some cases, the neuropathy may progress or become irreversible despite discontinuation of the medications.ModerateCaution is advised during concomitant use of agents with neurotoxic effects. Patients should be monitored closely for symptoms of neuropathy such as burning, tingling, pain, or numbness in the hands and feet. Since the development of peripheral neuropathy may be dose-related for many drugs, the recommended dosages should generally not be exceeded.Rotavirus vaccineThe administration of live, attenuated virus or bacterial vaccines during immunosuppressant or intense antineoplastic therapy may be associated with a risk of disseminated infection due to enhanced replication of vaccine virus or bacteria in the presence of diminished immune competence. Patients may be immunosuppressed if they have recently received Paclitaxel.MajorIn general, live virus or bacterial vaccines should not be used in patients receiving Paclitaxel.Strontium-89 ChlorideThe concomitant use of bone marrow depressants and strontium-89 chloride may have additive myelosuppressive effects. ModeratePatients should be monitored for excessive bone marrow suppression during treatment with strontium-89 chloride. Dose reductions of the other bone marrow depressants may be necessary.TrastuzumabVORICONAZOLEVoriconazole may increase the serum concentration of paclitaxel by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Inj Store in refrigerator.

Paclitaxel should not be used during pregnancy or lactation. It should be used with caution in patients with any pre-existing heart disease, liver disease, bone marrow disorders, history of allergic reaction or if have any allergy.