Bezafibrate

Bezafibrate is anti-hyperlipidimic agent. Bezafibrate is used to reduce high blood fats and cholesterol levels.


Brands
Adult Dose
Dose: 200 mg
Single Dose: 200 (200)
Frequency: 8 hourly
Route: PO
Instructions: With or after food.
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Priopionic Acid. It belongs to Lipid lowering agents pharmacological group on the basis of mechanism of action. The Molecular Weight of Bezafibrate is 361.80. Its pKa is 3.61.
Contraindications
Bezafibrate is contraindicated in conditions like Renal failure,Liver cirrhosis,Nephrotic syndrome,Hypoalbuminaemia.
Effects
The symptomatic adverse reactions produced by Bezafibrate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, GI distention, Myositic syndrome.
Indications
Bezafibrate is primarily indicated in conditions like Hypercholesterolaemia, Prophylaxis of NSAID-associated gastric or duodenal ulcer.
Interactions
Bezafibrate is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCerivastatin SodiumCerivastatin sodium causes additive toxicity with BezafibrateFluvastatinIncreased risk of myopathy when fibrates (e.g Bezafibrate) given with statins (e.g Fluvastatin). These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store in a well closed container, Below 40°C.
Warnings
Bezafibrate should not be given to patients with severe liver or kidney impairment, primary biliary cirrhosis, gallstone or gallbladder disorder or hypoalbuminaemic state.
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