Oxaprozin

Oxaprozin is NSAID (non steroidal antinflammatory drug). Oxaprozin is one of the newest of the propionic acid derivative. It relieves pain and reduces inflammation and fever. It has a very long half life and it can be given once a day. Because of this long half life dose adjustment should be made at intervals no shorter than five days to two weeks.

Brands
OX-600 DAYPRO
Adult Dose
Dose: 600 mg
Single Dose: 600 (600)
Frequency: 24 hourly
Route: PO
Instructions:
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
belongs to Propionic Acid. It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action and also classified in Analgesics and Anti-inflammatory Agents pharmacological group.The Molecular Weight of Oxaprozin is 293.30. Its pKa is 4.3.
Contraindications
Oxaprozin is contraindicated in conditions like Haemorrhage,GI diseases.
Effects
The severe or irreversible adverse effects of Oxaprozin, which give rise to further complications include Anemia, Pancreatitis, Leucopenia, Agranulocytosis.The symptomatic adverse reactions produced by Oxaprozin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Anorexia, Abdominal pain, Rashes, Dysuria, Sleep disturbance, Weight gain, StomatitisX, Rectal bleeding, Edema, Weight loss, GI hemorrhage, Increased intracranial pressure, CNS depression, Serum sickness, BP alteration, GI ulceration.
Indications
Oxaprozin is primarily indicated in conditions like Osteoarthritis, Rheumatoid arthritis.
Interactions
No data regarding the interactions of Oxaprozin was found.
Interfrence
Abnormal LFTs
Risks
Drug should not be given to Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Oxaprozin should be used with caution in patients with any liver or kidney disease, blood disorders, ulcers, heart disease, alcohol use, high blood pressure, eye disease or allergies (especially drug allergies). It should be used with caution when performing tasks requiring alertness. Limit alcohol intake as it may intensify the drowsiness effect of this medication and make stomach or intestines more likely to bleed. Do not take aspirin without consulting the doctor (check the ingredients of any nonprescription medication because it may contain aspirin). Caution is advised when this drug is used in the elderly. It should be used during pregnancy or lactation only if clearly needed. Use of this drug during the last 6 months of pregnancy is not recommended.
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