Nimesulide

Nimesulide is NSAID ( non steroidal antinflammatory drug) reported to be selective inhibitor of cyclo-oxygenase-2 (COX-2) it has been given by mouth or rectally for inflammatory condition, fever and pain.


Adult Dose
Dose: 0 to 100 mg
Single Dose: 50 (50)
Frequency: 12 hourly
Route: PO
Instructions: Increase upto 200mg bid.
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
. It is of Synthetic origin and belongs to Sulphon Anilide. It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action and also classified in Analgesics and Anti-inflammatory Agents pharmacological group.The Molecular Weight of Nimesulide is 308.30.
Contraindications
Nimesulide is contraindicated in conditions like GI ulceration,GI hemorrhage.
Effects
The severe or irreversible adverse effects of Nimesulide, which give rise to further complications include Stevens johnson syndrome, lyells syndrome, hepatoxicity.Nimesulide produces potentially life-threatening effects which include Anaphylaxis. which are responsible for the discontinuation of Nimesulide therapy.The signs and symptoms that are produced after the acute overdosage of Nimesulide include Hypotension, Hypothermia.The symptomatic adverse reactions produced by Nimesulide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Drowsiness, Nausea, Pain, VertigoX, Thrombocytopenia, Melena.
Indications
Nimesulide is primarily indicated in conditions like Bursitis, Fever, fever, Gynecological infections, Inflammation, Osteoarthritis, Pain, Rheumatoid arthritis, Tendinitis, Thrombophlebitis, Trauma, and can also be given in adjunctive therapy as an alternative drug of choice in Ent infections.
Interactions
No data regarding the interactions of Nimesulide was found.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
Nimesulide must be used with care among patients with a history of bleeding, with illnesses of the upper gastrointestinal tract and to subjects undergoing treatment with anticoagulants or drugs that inhibit platelet aggregation. The patients must be under direct medical supervision while taking substances with limited gastric tolerance at the same time. Since the drug is eliminated mainly through the kidneys, patient with the renal insufficiency must have a lower dosage depending on the glomerular filtration rate. The product must not be administered to the patient with severe renal insufficiency. The product can cause water retention, therefore it must not be administered to the patient with reduced cardiac function. Patients whose activity require alertness must take the product with care in case they notice drowsiness or vertigo during therapy . Cases of visual disturbances when using other non-steroidal anti-inflammatory drugs have been reported, If eye problems appear, the treatment must be interrupted and an eye examination must be performed.
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