Naphazoline

Naphazoline is a sympathomimetic agent with marked alpha-adrenergic activity. Chemically Naphazoline is 2-(1-naphthylmethyl)-2-imidazoline. Naphazoline is used topically on nasal mucosa where its vasoconstrictor effect leads to reduce secretion and mucosal swelling (e.g in allergic rhinitis). Prolonged use may lead to rebound nasal congestion and secretion. Naphazoline is also used in allergic and inflammtory condition of eyes.

Brands
NAPHTEARS NAPHCON FORTE NAPHCON-A NAFAMINE EFEMOLINE OCULOSAN DELTARHINOL PHENERAZOLINE ORBANAPH ORBACLEAR NALOROPTIC RHINOSONE CURINE CURALL-A RHINOSONE-P OCUCON-A MURINE CLEAR EYES
Adult Dose
Dose: 0.09%
Single Dose: 0.09 (0.09)
Frequency: 6 hourly
Route: Intra Nasal
Instructions: 1-2 drops or spray in each nostril, not more than 3 to 5 days
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose: 0.05%
Single Dose: 0.05 (0.05)
Frequency: As recommended.
Route: Children aged 7 years & over
Instructions:
Characteristics
belongs to Imidazole. It belongs to Alpha adrenergic agonist pharmacological group on the basis of mechanism of action. The Molecular Weight of Naphazoline is 210.27. It is weakly acidic drug, 3.99% solution of the drug is isotonic.
Contraindications
Naphazoline is contraindicated in conditions like Asthma,Diabetes mellitus,Narrow-angle glaucoma.
Effects
The severe or irreversible adverse effects of Naphazoline, which give rise to further complications include Rebound congestion, Increased IOP (intraocular pressure).The symptomatic adverse reactions produced by Naphazoline are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Nervousness, Dry mouth, Irritation, Sneezing, Blurring of vision, Mydriasis, Stinging on application, Dry mouth, nervousness, Nervousness, dizziness.
Indications
Naphazoline is primarily indicated in conditions like Corneal vascularity, Hyperaemia, Itching, Nasal congestion, and can also be given in adjunctive therapy as an alternative drug of choice in Sinusitis.
Interactions
No data regarding the interactions of Naphazoline was found.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, and Cardiac / Hypertensive Patients.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Eye Drops Store Below 40°C. Do not Freeze.
Warnings
Use topical decongestant only in acute conditions, not longer than 3 to 5 days. Naphazoline should be used sparingly in all patients, especially in infants, children and in cardiac patients.
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