Moxonidine

Moxonidine is antihypertensive agent acts on imidazoline sub-type 1 receptors to the brain medula. Used alone or in combination therapy to reduce mild to moderate blood pressure. May cause dry mouth, headache, nausea and insomnia.


Brands
Adult Dose
Dose: 0.002 to 0.008 mg/kg
Single Dose: 0.005 (0.005)
Frequency: As recommended.
Route: PO
Instructions: As required
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
belongs to Methylpyrimidine. It belongs to Alpha-2 adrenergic agonist pharmacological group on the basis of mechanism of action and also classified in Antihypertensive Agents pharmacological group.The Molecular Weight of Moxonidine is 241.70.
Contraindications
'Moxonidine is contraindicated in conditions like Depression,Glucoma,Parkinsonism,Raynaud''s phenomenon.'
Effects
The symptomatic adverse reactions produced by Moxonidine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Tiredness, Headache, Anorexia, Constipation, Sleep disturbancesX, Dry mouth, Itching, Burning, Dry mouth, dizziness.
Indications
Moxonidine is primarily indicated in conditions like Hypertension, Mild iron-deficiency anaemias.
Interactions
Moxonidine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAldesleukinEnhanced hypotensive effect when aldesleukin given with Moxonidine.AlprostadilEnhanced hypotensive effects when alprostadil given with Moxonidine.DiazoxideEnhanced hypootensive effect when Diazoxide given with Moxonidine.HydrochlorothiazideConcomitant administration of moxonidine and hydrochlorothiazide is not indicated, as hypotensive effect of both drugs may be enhanced. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Store in a well closed container.
Warnings
Moxonidine should not be given to patients with conduction disorder, bradycardia, severe arrhythmias, severe heart failure, severe ischaemic heart disease, severe liver or kidney impairment or history of angioedema. It should not be stopped abruptly but should be withdrawn gradually over 2 weeks.
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