Moclobemide

Moclobemide is oral antidepressant agent acts by selective inhibiton of monoamine oxidase type A in the brain. Increases brain monoamines by reducing their enzyme breakdown. Acts more rapidly than earlier MAOIs such as Phenelzine, and causes fewer side effects. Moclobemide is effective in the treatment of depression in patients who are allergic or untreated with tricyclic antidepressants.

Brands
AURORIX
Adult Dose
Dose: 150 mg
Single Dose: 150 (150)
Frequency: 24 hourly
Route: PO
Instructions: Maintenance.
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
belongs to Benzamide. It belongs to Psychotherapeutic Drugs and Antidepressant pharmacological group.The Molecular Weight of Moclobemide is 268.70.
Contraindications
Moclobemide is contraindicated in conditions like Phaeochromocytoma,Thyrotoxicosis,Acute confusion states.
Effects
The symptomatic adverse reactions produced by Moclobemide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Constipation, Insomnia, Confusion, Nausea and vomiting, Visual disturbances, Confusion, dizziness, parasthesia.
Indications
Moclobemide is primarily indicated in conditions like Autoimmune conditions, Depression, Social phobia.
Interactions
Moclobemide is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAntazolineIncreased antimuscarinic and sedative effects when antihistamines (e.g Antazoline) given with MAOIs antidepressants (e.g Moclobemide).Apraclonidine (HCl)Bupropion (HCl)ADVICE: Avoid concomitant use with Moclobemide.MajorCimetidine (HCl)Clomipramine (HCl)CodeineDextromethorphanEphedrineFentanyl (Citrate)Fluoxetine (HCl)IbuprofenLevodopaOxypertineTheoretical potential for OXYPERTINE increasing the CNS STIMULANT effect of MOCLOBEMIDE. MajorPhenylephrine (HCl)Phenylpropanolamine (HCl)Pseudoephedrine (HCl)Moclobemide results in hypertensive crisis with Pseudoephedrine (HCl) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store at room temperature. Protect from Moisture.
Warnings
Patient should be closely monitored during early antidepressant therapy until improvement in depression is observed because suicide is an inherent risk in depressed patients. Moclobemide should be avoided in exited or agitated patients or those with severe hepatic (liver) impairment. Care should also required in patients with thyrotoxicosis as moclobemide may precipitate hypertensive reaction.
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