Bethanechol (Cl)

Bethanechol is a cholinergic agonist and is mainly muscarinic in action. Chemically, it has the structural features of both methacholine and carbachol. Bethanechol (Cl) is resistant to hydrolysis by cholinesterase. Bethanechol (Cl) is used to stimulate the smooth muscle contraction of the urinary bladder and gastrointestinal tract. Administered orally or subcutaneously.

Brands

Adult Dose

Dose: 0.142 to 0.35 mg/kg
Single Dose: 0.25 (0.246)
Frequency: 8 hourly
Route: PO
Instructions: -

Neonatal

Dose: 0.6 mg/kg
Single Dose: 0.6 (0.6)
Frequency: 8 hourly
Route: Oral
Instructions: -

Paedriatic

Dose: 0.6 mg/kg
Single Dose: 0.6 (0.6)
Frequency: 8 hourly
Route: Oral
Instructions: -

Characteristics

. It is of Synthetic origin and belongs to Carbamate Ammonium Salt. It belongs to Cholinergic muscarinic agonist pharmacological group on the basis of mechanism of action and also classified in Antidotes pharmacological group.The Molecular Weight of Bethanechol (Cl) is 196.70. It is weakly acidic drug, 3.05% solution of the drug is isotonic.

Contraindications

Bethanechol (Cl) is contraindicated in conditions like Asthma,Epilepsy,Hyperthyroidism,Myocardial infarction,Parkinsonism,Bradycardia,Vagotonia,Intestinal obstruction,Hypotension,Pronounced vasomotor instability,Urinary outflow obstruction,Gastric obstruction,Recent intestinal anastomosis.

Effects

The signs and symptoms that are produced after the acute overdosage of Bethanechol (Cl) include Severe hypotension.The symptomatic adverse reactions produced by Bethanechol (Cl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Blurred vision, Frequent of micturition, Lower abdominal cramps.

Indications

Bethanechol (Cl) is primarily indicated in conditions like Adynamic ileus, Gastric atony, Gastric retention, Mega colon, Reflux oesophagitis, Urinary retention, and can also be given in adjunctive therapy as an alternative drug of choice in Urinary retention.

Interactions

Bethanechol (Cl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAdrenalineNeostigmineProcainamide (HCl)QuinidineTacrine (HCl)Technetium Tc-99m DisofeninBethanechol (Cl) may decrease gallbladder emptying thus delaying gallbladder clearance of technetium Tc 99m disofenin.Technetium Tc-99m lidofeninBethanechol (Cl) may decrease gallbladder emptying, thus delaying gallbladder clearance of technetium Tc 99m lidofenin. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Interfrence

Risks

Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Storage

Inj Store Below 40°C. Do not Freeze. Tab Store in a well closed container, Below 40°C.

Warnings

Avoid bethanecol in patients with intestinal or urinary obstruction, asthma or obstructive airway disease, cardiovascular disease including bradycardia or heart block or recent myocardial infraction, in hypotension, epilepsy, parkinsonism, hyperthyroidism, peptic ulcer and during pregnancy.

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