Methoxsalen

Methoxsalen is a furocoumarin produced by Amni majus and other plants. It increases the photo dynamic pigmentation of skin; it does not induce pigmentation in the absece of ultraviolet light. Methoxsalen is used in the treatment of vitiligo.Severe sunburning can occur with topical application; Methoxsalen is customary to protect the surrounding skin with a sunscreen. Administered orally and topically, but the drug should be used orally only under medical supervision as it may cause gastrointestinal upset and central nervous toxicities after oral administration.

Brands
LUKODERMINE LUKODERMINE LUMINE AMMOIDIN AMMOIDIN OXSORALEN OXSORALEN SOROLAN SOROLAN
Adult Dose
Dose: 20 mg
Single Dose: 20 (20)
Frequency: As recommended.
Route: PO
Instructions: As Required
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
Methoxsalen also known as Xanthotoxin. . It is of Synthetic origin and belongs to Benzopyran. It belongs to Antidotes and Photosensitizer pharmacological group.The Molecular Weight of Methoxsalen is 216.16.
Contraindications
Methoxsalen is contraindicated in conditions like Systemic lupus erythematosus,Dermatomyositis,Porphyria,Xeroderma pigmentosum,Hereditary dysplastic nevus syndrome,Trichothiodystrophy,Cockaynes syndrome,Previous malignant melanoma,Gorlins syndrome,Blooms syndrome.
Effects
Methoxsalen produces potentially life-threatening effects which include Skin cancer. which are responsible for the discontinuation of Methoxsalen therapy.The symptomatic adverse reactions produced by Methoxsalen are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Insomnia, Nervousness, Pruritus, VertigoX, Itching, Hypotension, Depression, Edema, Peeling of skin, nervousness, Nervousness, dizziness.
Indications
Methoxsalen is primarily indicated in conditions like Alopecia, Atopic dermatitis, Chronic dermatitis, Chronic psoriasis, Eczema, Lichen planus, Mycosis fungoides, Polymorphous light eruption, Psoriasis, Vitiligo.
Interactions
Methoxsalen is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementFosphenytoinPhenytoin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab, Oint, Cream, Lotion Store Below 40°C. Do not Freeze. Protect from Sunlight.
Warnings
Certain foods may cause reactions when eaten during methoxsalen therapy, try to avoid them, they include carrots, celery, figs, limes, mustard, parsley. This is not recommended for use during pregnancy. This increases sensitivity to sunlight, avoid exposure to sun 24 hours prior to using this medication, after use, avoid sun exposure for at least 8 hours, wear protective clothing (hats, gloves and UVA-absorbing sunglasses). Apply broad screen sunscreens (SPF 15) to all exposed skin including lips. Tell the doctor if patient have an allergy to sunlight, infection, lupus, porphyria, skin cancer, stomach trouble, cataracts, liver disease or heart and blood vessel disease.
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