Meropenem

Meropenem is an intravenous broad spectrum antibiotic derived from thienamycin. The actions, uses and adverse effects are similar to those of imipenem but unlike imipenem it does not need the addition of Cilastatin to prolong its action. It has a slightly greater activity against gram-negative aerobes and slightly less activity against gram positive anaerobes. Antibiotics require constant drug level in body for therapeutic effect. This is attained by taking the medicine at regular intervel of time throughout the day and night as prescribed.

Brands
PENRO Merem Merem MERONEM MERONEM XEPIME XEPIME ENGPAN CILIPENEM CILIPENEM MEROCIN CARNEM CARNEM DEMONEM DEMONEM DEMONEM DEMONEM MEROCON MEROCON
Adult Dose
Dose: 500 to 1000 mg
Single Dose: 750 (750)
Frequency: 8 hourly
Route: IV
Instructions: As required
Neonatal
Dose: 7.142 mg/kg
Single Dose: 7.1 (7.142)
Frequency: 8 hourly
Route: Intra Venous
Instructions: As required
Paedriatic
Dose: 25 to 0 mg/kg
Single Dose: 12 (12.5)
Frequency: As recommended.
Route: For meningitis
Instructions:
Characteristics
. It is of Semi Synthetic origin and belongs to Beta Lactum. It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.The Molecular Weight of Meropenem is 437.50. Its pKa is 2.9, 7.8.
Contraindications
Meropenem is contraindicated in conditions like Hypersensitivity,GI diseases.
Effects
The severe or irreversible adverse effects of Meropenem, which give rise to further complications include Pseudomembranous colitis, Thrombocytopenia, Stevens johnson syndrome, Stevens johnson syndrome, Eosinophilia, Eosinophilia, Seizures.Meropenem produces potentially life-threatening effects which include Hypersensitivity reactions. which are responsible for the discontinuation of Meropenem therapy.The symptomatic adverse reactions produced by Meropenem are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Vomiting, Diarrhea, Fever, Constipation, Abdominal pain, Rashes, Urticaria, Pruritus, Elevation of liver enzymes, Dermatitis, Reaction at injection site.
Indications
Meropenem is primarily indicated in conditions like Abdominal sepsis, Adult febrile neutropenia, Gynecological infections, Meningitis, Obstetric infections, Pneumonia, Pulmonary infections in cystic fibrosis, Septicaemia, Serious infections, Surface anaesthetic, Surgical anaesthesia.
Interactions
No data regarding the interactions of Meropenem was found.
Interfrence
Positive Coombs Test
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store in a well closed container, at room temperature, Between 20°C-25°C. Protect from Sunlight.
Warnings
Pseudomembranous colitis and hypersensitivity reactions have occured and often require immediate drug discontinuation, thrombocytopenia has been reported in patients with significant renal dysfunction, seizures have occurred in the patient with underlying neurological disorders (less frequent than with meropenem, safety and efficacy of meropenem have not been established for children
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