Lomefloxacin (HCl)

Lomefloxacin (HCl) is a difluorinated quinolone antibiotic. It has a broad spectrum of activity against aerobic gram negative bacteria. Lomefloxacin (HCl) is not available in any combination preparations. Lomefloxacin (HCl) is administered orally. Fluoroquinolones are extremely useful agents and an important therapeutic advance. They are relatively non-toxic, well tolerated broad spectrum agents. Their excellent bioavailibilty permits their use for treatment of variety of serious bacterial infections.


Adult Dose
Dose: 400 mg
Single Dose: 400 (400)
Frequency: 24 hourly
Route: PO
Instructions:
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Quinoline. It belongs to DNA Gyrase inhibitor pharmacological group on the basis of mechanism of action and also classified in Antimicrobial Agent pharmacological group.The Molecular Weight of Lomefloxacin (HCl) is 387.90. Its pKa is 5.99, 9.01.
Contraindications
Lomefloxacin (HCl) is contraindicated in conditions like Epilepsy,Hypersensitivity.
Effects
The severe or irreversible adverse effects of Lomefloxacin (HCl), which give rise to further complications include Seizures, Tendon rupture.The symptomatic adverse reactions produced by Lomefloxacin (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Vertigo, Headache, Nausea, Anorexia, Diarrhea, Myalgia, Confusion, Pruritus, Hallucination, Asthenia, Phlebitis, Arthralgia, Agitation, Leukopenia, Increased intracranial pressure.
Indications
Lomefloxacin (HCl) is primarily indicated in conditions like Acute bacterial diarrhea, Chronic bronchitis, Pyelonephritis, Transurethral surgery, Uncomplicated cystitis, UTI, and can also be given in adjunctive therapy as an alternative drug of choice in Surgical infections.
Interactions
Lomefloxacin (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementRutin (Vitamin P)Rutin may competitively inhibit action of Lomefloxacin (HCl). These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Increased in Serum AminotransferaseIncreased Alkaline Phosphatase Levels
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store Below 40°C. Protect from Sunlight and Heat.
Warnings
Lomefloxacin should be used with caution in patients with history of epilepsy, kidney disease, tendon problems, nervous system disorders, liver disease and of any allergy, including drug allergies. It should be used with caution while driving or performing tasks requiring alertness because it produce dizziness or lightheaded. Limit alcohol intake. Because this may produce sensitivity to the sun, avoid prolonged sun exposure, wear protective clothing and use a sunscreen when outdoors. It should be used only when clearly needed during pregnancy.
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