Epirubicin

Epirubicin is anthracycline antibiotic.It is an anticancerous agent. and has antineoplastic actions similar to doxorubicin. Epirubicin (HCl) is effective in the treatment of different cancers to slow or stop the growth of abnormal cells. Epirubicin (HCl) is used in combination with different anticancerous drugs to obtain most excellent therapeutic effects and reduce toxicity or unwanted effects.

Brands
ANTHRACIN ANTHRACIN E-RUBICIN FARMORUBICIN FARMORUBICIN FARMORUBICIN RD FARMORUBICIN RD EPIRUBICIN EPIRUBICIN
Adult Dose
Dose: 60 to 90 mg/ sq.meter
Single Dose: 75 (75)
Frequency: As recommended.
Route: IV
Instructions: Every 3 weeks.
Neonatal
Paedriatic
Characteristics
Epirubicin (HCl) is the derivative of Epirubicin. It is of Semi Synthetic origin and belongs to Naphthacene. It belongs to Antineoplastic Agent, Anthracycline Antibiotic pharmacological group.The Molecular Weight of Epirubicin is 580.00. Its pKa is 8.1.
Contraindications
Epirubicin is contraindicated in conditions like Hypersensitivity.
Effects
The severe or irreversible adverse effects of Epirubicin, which give rise to further complications include Vomiting, Dehydration, Hypersensitivity, Hives.Epirubicin produces potentially life-threatening effects which include Cardiotoxicity, Neutropenic sepsis. which are responsible for the discontinuation of Epirubicin therapy.The signs and symptoms that are produced after the acute overdosage of Epirubicin include Nausea, Vomiting, Cardiotoxicity, Myelotoxicity.The symptomatic adverse reactions produced by Epirubicin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Fatigue, Nausea, Vomiting, Alopecia, Diarrhea, Mucositis, Urticaria, Hair loss, Hot flushes, Lassitude, Local venous flare.
Indications
Epirubicin is primarily indicated in conditions like Bladder carcinoma, Breast cancer, Gastric cancer, Lung cancer, Lymphoma, Ovarian cancer.
Interactions
No data regarding the interactions of Epirubicin was found.
Interfrence
Liver Function Test (LFT) Complete blood cell countEvaluation of AST levels
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj (reconstituted soln) Store in refrigerator. Protect from Sunlight. Use within 24 hrs if kept at room temperature. Vial Store in refrigerator. Protect from Sunlight.
Warnings
Epirubicin should be used with caution in elderly, toxic effects are more marked because the clearance is reduced. In hepatic disease, dose reduction according to degree of hepatic failure is advised to avoid serious toxicity. It should be administered only under the supervision of a physician experienced in the use of the chemotherapy. The FDA currently recommends that procedures for proper handling and disposal of antineoplastic agents be considered. Epirubicin may cause increase in skin sensitivity towards sunlight. Donot have any vaccinations during its use. Cautions should be taken in allergic patients.
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