Enoxaparin

Enoxaparin is anticoagulant agent which has antithirombotic properties. Enoxaparin is a low molecular weight heparin fraction. Enoxaparin is prepared commercially from bovine lung and porcine intestinal mucosa.


Adult Dose
Dose: 20 mg
Single Dose: 20 (20)
Frequency: 24 hourly
Route: SC
Instructions: For 7-10 Days
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
enoxaparin sodium is the derivative of Enoxaparin. It is of Semisynthetic origin. It belongs to Low Molecular Weight Heparin pharmacological group.The Molecular Weight of Enoxaparin is 3800.00.
Contraindications
Enoxaparin is contraindicated in conditions like Peptic ulcer,Hypersensitivity,Acute musculoskeletal disorders,Relief of sore throat,Initial treatment of acute conditions,Pain management,Acute pain (including pain following dental or orthopaedic surgery).
Effects
Enoxaparin produces potentially life-threatening effects which include Bleeding. which are responsible for the discontinuation of Enoxaparin therapy.The symptomatic adverse reactions produced by Enoxaparin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Diarrhea, Fever, Confusion, Pruritus, Erythema, Allergic reactions, Thrombocytopenia, Bruising, Anemia, Purpura, Bleeding, Hypercalcemia, Bruising, Confusion, injection site pain.
Indications
Enoxaparin is primarily indicated in conditions like Ischaemic heart disease, Myocardial infarction, Prophylaxis of venous thromboembolism, Thrombosis, Treatment of deep vein thrombosis, Unstable angina.
Interactions
Enoxaparin is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholAprotininAspirinIn those Patients receiving enoxaparin, risk of epidural or spinal hematoma become develop which may increase by concomitant use of enoxaparin with aspirin.MajorAspirin should avoid in patients receiving enoxaparin.Strickly monitor the sign and symptoms of neurologic impairement.DipyridamoleRivaroxabanAnticoagulant, An additive effect on Anti-factor Xa Activity increase Bleeding riskCare should be taken due to increase risk of bleedingTenecteplaseConcurrent use is usually not recommended but may be required in some cases. If both medicines are prescribed together, change of dose may be required.Warfarin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Periodic blood count
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store Between 15°C-25°C. Do not Freeze.
Warnings
Enoxaparin should be used with caution in patients with liver, kidney or heart disease, eye problems, bleeding problems, blood disorders, stomach or intestinal problems, uncontroledartivial high blood pressure, stroke, diabetic ratinopathy, eye, brain or spinal cord surgery and of allergies especially to drugs. This medication should be used only when clearly needed during pregnancy or lactation.
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