Betahistine (HCl)

'Betahistine (HCl) is a histamine analogue used as a vasodialtor to reduce the frequency of attacks of dizziness in Menier''e disease, administered orally.'


Adult Dose
Dose: 16 mg
Single Dose: 16 (16)
Frequency: 8 hourly
Route: PO
Instructions: Initial, increase dose as per response
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
. It is of Synthetic origin and belongs to Amino Pyridine. It belongs to Histamine agonist pharmacological group on the basis of mechanism of action and also classified in H3 Antagonist pharmacological group.The Molecular Weight of Betahistine (HCl) is 209.10. Its pKa is 3.5.
Contraindications
Betahistine (HCl) is contraindicated in conditions like Asthma,Peptic ulcer,Phaeochromocytoma,Rhinitis,Urticaria.
Effects
The signs and symptoms that are produced after the acute overdosage of Betahistine (HCl) include Nausea, Vomiting, Seizures, Dyspepsia, Ataxia.The symptomatic adverse reactions produced by Betahistine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Drowsiness, Nausea, Dyspepsia.
Indications
Betahistine (HCl) is primarily indicated in conditions like Hearing loss, Menieres disease, Tinnitus, Vertigo.
Interactions
Betahistine (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholDiphenyl Pyraline These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store in a well closed container, at room temperature, Below 30°C.
Warnings
Betahistine should not be given to neonates, childrens, during pregnancy and lactation and in patients with pheochromocytoma. It should be used with caution in patients with asthma or peptic ulcer.
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