Dorzolamide

Dorzolamide (HCl) reduces intraocular (eye) pressure and is used to treat glaucoma and elevated intraocular (eye) pressure. Dorzolamide and bringolamide both work by inhibiting earbonic cmhydrase (isoemynell which is found in the ciliary body epithelium. This reduce the formation of biearbonate ions, which recluces fluid transport and thus IOP. reduces IOP by reducing aqueous humar production. They are licensed for use in pateints resistant to beta-blokess or those in whom beta-blockess are contra-indicated. They are used alone or as an adjuant to a topical beta-blocker.

Brands
GLANTRIM SYNIGAN CODOR Z DORZ E/D HISOPT TIMOTEK-D DOZYPRESS-T TRUSOPT COSOPT CO-DORZAL TILOMIDE GLAZOL-T TIMOZOL TIMOREX D DORTIM DASURA ISDORZ + T ISDORZ
Adult Dose
Dose: 1 mg
Single Dose: 1 (1)
Frequency: 8 hourly
Route: Ophthalmic
Instructions: -
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
Dorzolamide (HCl) is the derivative of Dorzolamide. It is of Synthetic origin and belongs to Sulphonamide. It belongs to Opthalmic Products and Antiglaucoma pharmacological group.The Molecular Weight of Dorzolamide is 360.90.
Contraindications
Dorzolamide is contraindicated in conditions like Renal impairment,Hyperchloremic acidosis.
Effects
The symptomatic adverse reactions produced by Dorzolamide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Inflammation, Nausea, Urticaria, Burning, Asthenia, Lacrimation, Conjunctivitis, Photophobia, Ocular irritation, Vision disturbances, Tearing, Keratitis, Stinging, Local allergies, Xerophthalmia, Rarely hypersensitivity reactions.
Indications
Dorzolamide is primarily indicated in conditions like Ocular hypertension, Open-angle glaucoma, Pseudoexfoliative glaucoma, Raised iop.
Interactions
No data regarding the interactions of Dorzolamide was found.
Interfrence
Not well documented
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Eye Drops Store Below 40°C. Protect from Sunlight and Heat.
Warnings
The preservative in this medication may be absorbed by soft contact lenses; therefore, it is recommended that soft contact lenses not be worn while using this medication. Dorzolamide should not be administered to patients with carbonic anhydrase inhibitor hypersensitivity. In addition, since dorzolamide is a sulfonamide derivative, it should not be used in patients with sulfonamide hypersensitivity. Topical administration of dorzolamide can result in systemic absorption. In sulfonamide-sensitive patients, administration of sulfonamides by any route can precipitate a possibly severe reaction. Its use as a single agent is insufficient for the management of closed-angle glaucoma. The use of multiple dose containers of ophthalmic products has been associated with bacterial keratitis. Inadvertent contamination of the product may occur if the patient has an ocular infection, or corneal abrasion. If there is any damage to the ocular epithelial surface dorzolamide should be used with caution. It should be used with caution in patients with hepatic disease. It is classified as pregnancy category C. Should be use during pregnancy only if the benefits outweigh the possible risks to the fetus. Cuation:- Systemic alesorption follows topical application; history of renal calculi; chronic corneal defects, history of intra-ocular surgury.
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