DAXOTEL DAXOTEL TEXOT TAXOTERE DOCETAXEL DOCETAXEL MEBREXEL MEBREXEL DONATAXEL EBEDOCE EBEDOCE DOZEP DOCETAXEL VARIFARMA DOCETAX DOCETAX DOCEKABIR DOCEKABIR

Dose: 60 to 100 mg/ sq.meter
Single Dose: 80 (80)
Frequency: As recommended.
Route: IV Inf
Instructions: Over 1 hour, repeated every 3 weeks

Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group

Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group

. It is of Semi Synthetic origin and belongs to Taxol Trihydrate. It belongs to Antineoplastic Agent, Antimicrotubular pharmacological group.The Molecular Weight of Docetaxel is 861.94.

Docetaxel is contraindicated in conditions like Neutropenia,Severe liver impairment.

The severe or irreversible adverse effects of Docetaxel, which give rise to further complications include Hypersensitivity reactions, Neurotoxicity, Sensory neuropathy.Docetaxel produces potentially life-threatening effects which include Neutropenia, Fluid retention syndrome. which are responsible for the discontinuation of Docetaxel therapy.The signs and symptoms that are produced after the acute overdosage of Docetaxel include Neutropenia, Mild paresthesia, Cutaneous reactions, Asthenia.The symptomatic adverse reactions produced by Docetaxel are more or less tolerable and if they become severe, they can be treated symptomatically, these include Fatigue, Nausea, Vomiting, Alopecia, Diarrhea, Mucositis, Fever, Urticaria, Pruritus, Malaise, Weight gain, Flushing, Arthralgia, StomatitisX, Elevation of liver enzymes, Thrombocytopenia, Neutropenia, Eruptions, Erythematous rash, Cutaneous reaction, Nail discoloration, Reaction at injection site, Onycholysis.

Docetaxel is primarily indicated in conditions like Gastric cancer, Metastatic carcinoma of breast, Non-small cell lung carcinoma, Ovarian cancer, Pancreatic cancer, Squamous cell carcinoma, Squamous cell carcinoma of head, and can also be given in adjunctive therapy as an alternative drug of choice in Advanced or metastatic breast cancer.

Docetaxel is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCyclosporin ADoxorubicin (HCl)ErythromycinKetoconazoleRutin (Vitamin P)Rutin (Vitamin P) by mouth may counteract docetaxel-fluid retention. TerfenadineVORICONAZOLEVoriconazole may increase the serum concentration of docetaxel by decreasing its metabolism. Consider using a non-interacting antifungal or monitor for changes These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Liver Function Test (LFT) Complete blood cell count

Drug should not be given to Pregnant Mothers, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Inj Store in refrigerator.

Docetaxel should be used cautiously in patients with pre-existing edema, ascites, or effusions, in hepatic disease because the drug is hepatically metabolized. It should not be given to patients with bilirubin levels greater than the upper limit of normal (ULN) or to patients with SGOT and/or SGPT greater than 1.5 times the ULN concomitant with alkaline phosphatase > 2.5 times the ULN. Bilirubin, SGOPT or SGPT and alkaline phosphatase values should be obtained before each cycle of docetaxel. It should be used with caution in patients with a baseline neutrophil count of less than 1500 cells/cubic mm, with any pre-existing heart disease, bone marrow disorders, or a history of allergic reactions. It is classified as pregnancy category D. It is not recommended during pregnancy or lactation.