Dipyrone

Dipyrone is a pyrazolone analgesic and antipyretic drug, now seldom used because of its side effects. Dipyrone is NSAID (non-steroidal anti-inflammatory drug). Dipyrone is used in severe pain when no alternative is available


Adult Dose
Dose: 0.8 to 1.6 g
Single Dose: 1.2 (1.2)
Frequency: 24 hourly
Route: IV/IM
Instructions:
Neonatal
Paedriatic
Characteristics
Dipyrone also known as Methampyrone, Methampyrone, Methampyrone. . It is of Synthetic origin and belongs to Aminophenatone. It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action and also classified in Analgesics and Anti-inflammatory Agents pharmacological group.The Molecular Weight of Dipyrone is 351.40.
Contraindications
Dipyrone is contraindicated in conditions like G6pd deficiency,Hepatic porphyria.
Effects
The severe or irreversible adverse effects of Dipyrone, which give rise to further complications include Blood dyscrasias, Agranulocytosis, Shock.The symptomatic adverse reactions produced by Dipyrone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Rashes, Urticaria, Asthma, Pain at injection site.
Indications
Dipyrone is primarily indicated in conditions like Biliary colic, Genitourinary tract colic, Headache, Muscular spasm, Neoplasms, Pain, Refractory pyrexia, Rheumatic diseases, Toothache, Trauma, and can also be given in adjunctive therapy as an alternative drug of choice in Surgery.
Interactions
Dipyrone is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementPhenobarbitone These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj,tabs,syrups,drops Store in a well closed container, . Protect from Sunlight and Heat.
Warnings
Dipyron should be used with caution in asthmatic patients, in neonates and during pregnancy.
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