Benzylpenicillin (Na or K)

Benzylpenicillin (Na or K) is a BETA-LACTUM antibiotic and has a bactericidal action against gram-poisitve bacteria, gram-negative cocci, some other gram-negative bacteria, spirochetes, and actinomycetes. It exerts its killing action on growing and dividing bacteria by inhibiting bacterial cell wall synthesis.Benzylpenicillin (Na or K) is used in treatment of a variety of infections including abscess, actinomycosis, anthrax, bites and stings, diptheria etc.

Brands
Adult Dose
Dose: 85.71 to 171.42 mg/kg
Single Dose: 130 (128.565)
Frequency: 24 hourly
Route: IV
Instructions: For 2-4 Weeks
Neonatal
Dose: 25 to 50 mg/kg
Single Dose: 38 (37.5)
Frequency: 6 hourly
Route: Intravenous
Instructions:
Paedriatic
Dose: 25 to 50 mg/kg
Single Dose: 38 (37.5)
Frequency: 6 hourly
Route: Intra Venous
Instructions: -
Characteristics
Benzylpenicillin (Na or K) also known as Crystallin Penicillin G, Crystallin Penicillin G. . It is of Semi Synthetic origin and belongs to Penicillin. It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Penicillin pharmacological group.The Molecular Weight of Benzylpenicillin (Na or K) is 356.40. Its pKa is 2.8.
Contraindications
Benzylpenicillin (Na or K)
Effects
The severe or irreversible adverse effects of Benzylpenicillin (Na or K), which give rise to further complications include Convulsions, Renal damage, Hemolytic anemia, Hypersensitivity reactions, Bone marrow hypoplasia, Jarisch herxheimer reaction, Cation intoxication.Benzylpenicillin (Na or K) produces potentially life-threatening effects which include Anaphylaxis. which are responsible for the discontinuation of Benzylpenicillin (Na or K) therapy.The symptomatic adverse reactions produced by Benzylpenicillin (Na or K) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Skin rash, Local reactions.
Indications
Benzylpenicillin (Na or K) is primarily indicated in conditions like Bacterial endocarditis, Bacterial infections, Meningococcal disease, Muscle relaxation, Muscle relaxation for surgery or intubation, Penicillin sensitive infections.
Interactions
Benzylpenicillin (Na or K) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementColestipol (HCl) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Alter laboratory test values of 17-Hydroxycorticosteroids,glucose & 17-ketosteroids Alter laboratory test values of 17-Ketogenic Steroids,PSP test,Thyroid Function Test.
Risks
Drug should not be given to Pregnant Mothers, and Cardiac / Hypertensive Patients.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store in a well closed container, at room temperature, Below 30°C.
Warnings
Benzylpenicillin should be used with caution in patients with history of allergy, especially to drugs and in patient hypersensitive to penicillin. Care is necessary if very high dose of penicillin is given, especially if renal (kidney) function is poor. Renal and hematological status should be monitored during prolonged and high dose therapy.
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