Cyclizine

Cyclizine is an H1 antihistaminic agent. Cyclizine is used as an antiemetic and anti-nauseant. Chemically Cyclizine is 1-(diphenylmethyl)-4-methylpiperazine. Cyclizine is effective to prevent or treat nausea, vomiting and dizziness caused by motion sickness. Cyclizine is administered intramuscularly. Abone statement is correct help but incorrect for its adminstrtion becaouse it is adminstered in oral drug and syrup form and IM through injection.

Brands
MARZINE MARZINE MARZINE MIGRIL NAUSIN TAGRIL SHIFAZINE MEDIZINE
Adult Dose
Dose: 50 mg
Single Dose: 50 (50)
Frequency: 8 hourly
Route: PO,IV,IM
Instructions:
Neonatal
Dose: Not rcommended in this age goup
Single Dose:
Frequency:
Route:
Instructions:
Paedriatic
Dose: 2.5 mg/kg
Single Dose: 2.5 (2.5)
Frequency: As recommended.
Route: Oral
Instructions: As Required
Characteristics
Nausin, Nausin, Nausin are the derivatives of Cyclizine. It is of Synthetic origin and belongs to Piperazine. It belongs to H1-antagonist pharmacological group on the basis of mechanism of action and also classified in Antiemetic/Antivertigo Agents pharmacological group.The Molecular Weight of Cyclizine is 266.40.
Contraindications
Cyclizine
Effects
The severe or irreversible adverse effects of Cyclizine, which give rise to further complications include Tardive dyskinesia, Neorologic effects.Cyclizine produces potentially life-threatening effects which include Neuroleptic Malignant Syndrome, Neuroleptic malignant syndrome. which are responsible for the discontinuation of Cyclizine therapy.The symptomatic adverse reactions produced by Cyclizine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Drowsiness, Restlessness, Tachycardia, Constipation, Insomnia, Nervousness, Blurred vision, Urinary retensionX, Urticaria, Dryness of mouth, Visual hallucinations, nervousness, Nervousness.
Indications
Cyclizine is primarily indicated in conditions like Motion sickness, Nausea and vomiting, Nausea and vomiting (chemotherapy induced), Nausea and vomiting (palliative care), Vertigo, Vestibular disturbances, and can also be given in adjunctive therapy as an alternative drug of choice in Menieres disease.
Interactions
Cyclizine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholDiamorphine (HCl)Fentanyl (Citrate)Methohexitone (Na)OxycodoneThiopentone (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store Below 40°C. Do not Freeze. Protect from Sunlight and Moisture. Tab, Syrup Store in a well closed container, Below 40°C. Protect from Sunlight and Moisture.
Warnings
Patient should observe caution while driving or performing other task requiring alertness because it may produce dizziness. Cyclizine should be used with caution in patients with asthma, glaucoma, obstructive disease of gastrointestinal (GI) tract. It should be used with ceution becouse it is antihistemine and futher couse allerfic neetions which are alreedy perent in pateints with asthema glucome, GI dosease.
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