Benztropine (Mesylate)

Benztropine (Mesylate) is a synthetic compound combining the active moieties of atropine and diphenylhydramine. It has anticholinergic, antihistaminic and local anesthetic effects. Benztropine (Mesylate) is antimuscarinic drug of potency one quater that of atropine sulphate and an antihistaminic of potency equal to that of pyrilamine maleate. It also has an antispasmodic properties. Benztropine (Mesylate) is used as an antidyskinetic in the treatment of parkinsonism and for the control of extrapyramidal reactions. Administered orally, intramuscularly and intravenously.

Brands
Adult Dose
Dose: 0.007 to 0.014 mg/kg
Single Dose: 0.01 (0.0105)
Frequency: 24 hourly
Route: PO
Instructions: Initial
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
Benztropine (Mesylate) also known as Benzatropine. . It is of Synthetic origin and belongs to Tropane Alkaloid. It belongs to Cholinergic muscarinic antagonist pharmacological group on the basis of mechanism of action and also classified in Antiparkinson Agents pharmacological group.The Molecular Weight of Benztropine (Mesylate) is 403.50. Its pKa is 10.0.
Contraindications
Benztropine (Mesylate) is contraindicated in conditions like Glucoma,Prostatic hypertrophy.
Effects
The severe or irreversible adverse effects of Benztropine (Mesylate), which give rise to further complications include Blindness, Paralytic ileus.Benztropine (Mesylate) produces potentially life-threatening effects which include Paralytic ileus. which are responsible for the discontinuation of Benztropine (Mesylate) therapy.The signs and symptoms that are produced after the acute overdosage of Benztropine (Mesylate) include Nausea, Vomiting, Convulsions, Coma, Blurred vision, Dry flushed skin, Palpitations, Pyrexia, Delirium.The symptomatic adverse reactions produced by Benztropine (Mesylate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dry mouth, Blurred vision, Confusion, Hallucination.
Indications
Benztropine (Mesylate) is primarily indicated in conditions like Acute dystonic reactions, Idiopathic parkinsons disease, Postencephalitic parkinsonism.
Interactions
No data regarding the interactions of Benztropine (Mesylate) was found.
Interfrence
Frigs TLC procedures for measuring alkaloids in urine
Risks
Drug should not be given to Geriatrics, Neonates, and Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab, Inj Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Benztropine should be used with caution in patients with heart, liver, kidney or obstructive gastrointestinal (GI) diseases. Patient should observe caution while driving or performing other tasks requiring alertness because may impair mental or physical abilities. It should be used with caution in hot weather. Reduce dose or discontinue therapy if loss of appetite or weight occur.
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