Clemastine

Clemastine is antihistaminic agent. Chemically Clemastine is (+)-2-[2(p-chloro-a-methyl-a-phenylbenzyl)oxy]ethyl]-1-methylpyrrolidine. Clemastine is effective in providing relief from symptoms of allergies such as watery eyes, runny nose, itching and sneezing.


Adult Dose
Dose: 1 mg
Single Dose: 1 (1)
Frequency: 12 hourly
Route: PO
Instructions:
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose: 0.025 to 0.05 mg/kg
Single Dose: 0.038 (0.0375)
Frequency: 12 hourly
Route: Oral
Instructions: -
Characteristics
Clemastine Fumarate is the derivative of Clemastine. It is of Synthetic origin and belongs to Methyl Pyrolidine. It belongs to H1-antagonist pharmacological group on the basis of mechanism of action. The Molecular Weight of Clemastine is 460.00.
Contraindications
Clemastine is contraindicated in conditions like Hypersensitivity,Porphyria.
Effects
The severe or irreversible adverse effects of Clemastine, which give rise to further complications include CNS stimulation.The symptomatic adverse reactions produced by Clemastine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Fatigue, Nausea, Constipation, Dry mouth, Sedation, Skin rash, Gastralgia, Dry mouth.
Indications
Clemastine is primarily indicated in conditions like Advanced ovarian cancer, Allegic rhinopathies, Hay fever, Insect bites, Rhinitis, Symptomatic relief of allergy, Urticaria, and can also be given in adjunctive therapy as an alternative drug of choice in Anaphylactic reactions, Angioneurotic edema, Dermatitis, Drug eruptions, Eczema.
Interactions
No data regarding the interactions of Clemastine was found.
Interfrence
Risks
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Syrup Store in a well closed container, Below 40°C. Do not Freeze. Protect from Sunlight. Tab Store in a well closed container, Below 40°C. Protect from Sunlight and Moisture.
Warnings
Clemastine should be used with caution in bone marrow depression. Patients should observe caution while driving or performing other task requiring alertness because it may cause drowsiness. It should be used with caution in patients with urinary retention, history of bronchial asthma, hyperthyroidism, cardiovascular or liver disease. It should be used with caution in person with acute or chronic respiratory impairment, especially in children. Do not administer subcutaneously because irritation or lesion may occur.
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