NEWMAC NEWMAC NEWMAC ALERCID ALERCID ALERCID AFOXIN AFOXIN ZECLORIN ZECLORIN MACLACIN MACLACIN MACLACIN MACLACIN MEGAKLAR MEGAKLAR MEGAKLAR NEO-KLAR NEO-KLAR NEO-KLAR KLABID KLABID KLABID KLARY KLARY MACROCID MACROCID CLARIMYCIN HELICURE CLARION XR CLARION CLARION CLARION CLARIFED CLARIFED CLARABAC CLARABAC CLARITEK XL CLARITEK CLARITEK CLARITEK CLARITEK PYLOCLAR PYLOCLAR PYLOCLAR KLARIMAX KLARIMAX KLARIMAX DIAXIN LARITH LARITH LARITH LARITH LARITH XL CANTER CANTER CANTER IRZACLARE IRZACLARE CLAMONT CLAMONT CLAMONT SILKOCIN ULTIMA ULTIMA ULTIMA ULTIMA ROLITE ROLITE ROLITE CLAROCIN CLAROCIN CLAROCIN CLARITHRO CLARITHRO CLARITHRO CLARITHRO CLARITHRO-SR CLARITHRO XL CLAROMY CLAROMY CLARAMED CLARAMED CLARAMED CLARINEN CLARINEN MACPAR MACPAR CLORMOCIN ORAL SUSPENSION KLARIBACT KLARIBACT KLARIBACT MYCLAR-XL MYCLAR MYCLAR MYCLAR KLACID KLACID CLARIBEST CLARIBEST CLARIBEST ARKET ARKET ARKET CLARIFEN UNICLAR PFICID PFICID DUOMYCIN XL DUOMYCIN DUOMYCIN RITROCIN RAKACID RAKACID RAKACID RAKACID NOVICLAR NOVICLAR NOVICLAR CLARX CLARX CLARX EFELIDE RITHMO XL RITHMO RITHMO RITHMO RITHMO RITHMO CLARAZE CLARAZE CLARA CLARA CLARA CLARA CLARIZA XL CLARIZA CLARIZA LARIT LARIT LARIT LARIT CLITHOR CLITHOR CLITHOR T-KLAR T-KLAR T-KLAR E-CLAR E-CLAR E-CLAR BV-CLAR BV-CLAR BV-CLAR BV-CLAR RIOMED RIOMED RIOMED RANKER RANKER RANKER MACLARA MACLARA MACLARA VENRITH VENRITH VENRITH PIRAK PATHOCIN PATHOCIN PATHOCIN CLARITH CLARITH CLACIN CLACIN CLACIN KLARONIL KLARONIL KLARONIL NYCIN NYCIN KLAVOR KLAVOR KLAROFID KLAROFID KLARIFID KALARIN KALARIN KLARIFINE KLARIFINE CLARINAC CLARINAC CARICIN CARICIN CLARISTA CLARISTA CLARISTA MEDILAR MEDILAR THROMIK THROMIK TARITHROCID TARITHROCID TARITHROCID KAYLID KAYLID 2-LAR EZIKLAR EZIKLAR CLARACIN CLARACIN CLARICIN CLARICIN OCIN OCIN CLARIGEN KLARCAY KLARCAY KLARCAY BERICIN BERICIN KLARIDOX KLARIDOX KLARIDOX KLARAMINE CLANTONE CLANTONE WINKEM WINKEM CLARISCOT CLARISCOT CLARISCOT KAIRO RIMCIN BIOCLAR BIOCLAR BIOCLAR CLARISH CLARIVEL CLARIVEL CLARIVEL KLARID KLARID CLARICAM CLARICAM CLOSFIN CLOSFIN CLARASIA CLARASIA CLARASIA CLIFF CLIFF MEGAMYCIN MEGAMYCIN CLAFAX CLAFAX AWACLOR AWACLOR THERACID THERACID SYNTOXIN SYNTOXIN KLARICID-XL KLARICID-I.V KLARICID KLARICID KLARICID HEALCIN HEALCIN CLARILIDE CLARILIDE CLARILIDE NOVIBAXIN NOVIBAXIN CLARIREX CLARIREX CLAROLIVE CLAROLIVE CLARYAN CLARYAN CLAZAN CLAZAN CLATZ CLATZ CLATZ JAWACLAR JAWACLAR RITHCIN MACROCLAR MACROCLAR CLARIWITT CLARIWITT RESPIMAX RESPIMAX RESPIMAX KETEK KETEK KLARICINE ALRAL ALRAL INFECTIKLAR AMIGO AMIGO ARITHRO ARITHRO CLARIWEB CLARIWEB CLARIWEB CLAVORIN CLAVORIN CLAVORIN CLAVORIN KLARISEF KLARISEF AMICLAR AMICLAR RITHINEX RITHINEX RITHINEX CINCLAR CINCLAR RESCLEAR RESCLEAR MACCIN MACCIN WORPIN WORPIN RITEK RITEK CALARIDE CALARIDE CLARISET CLARISET CLARISET CLARISET CLARIWIN CLARIWIN RIZCID RIZCID VIKLAR VIKLAR KLAR KLAR KLERIC KLERIC HOMYCIN CLAROLID CLAROMIN PIRAK PIRAK CALMY CALMY KLATH KLATH KLARGO KLARGO KLARGO CLARITUS GEMGEN CLEIRO CLARIADVAN CLARIADVAN APRO SUSPENSION KLARI CLARINOM CLARINOM THROCIN THROCIN THROCIN KLARAZID KLARAZID LINCLAR LINCLAR CLARIFOLD CLARIWEL CLARIFASS CLARIFASS CLARMARK SAFRICID SAFRICID LERITHIN LERITHIN A-CLARO A-CLARO SYICLAR SYICLAR KLASH KLASH KALASAVE KALASAVE KALASAVE CRONEB CRONEB CLARIQUEN SUSPENSION APTICLAR APTICLAR CLARACT CLARACT CLARACT CLARACT FASCAR XL SIMCLAR ALVOGAR ALVOGAR

Dose: 500 to 0 mg
Single Dose: 250 (250)
Frequency: 12 hourly
Route: IV
Instructions: IV inj should be administer over 60 minutes for 2-5days

Dose: 7.5 mg/kg
Single Dose: 7.5 (7.5)
Frequency: 12 hourly
Route: Oral
Instructions: -

Dose: 7.5 mg/kg
Single Dose: 7.5 (7.5)
Frequency: 12 hourly
Route: Oral
Instructions: -

clarithromycine is the derivative of Clarithromycin. It is of Semi Synthetic origin and belongs to Hexopyranosyl. It belongs to Antibacterial (Proetin synthesis inhibitor) pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.The Molecular Weight of Clarithromycin is 748.00. Its pKa is 8.3.

Clarithromycin is contraindicated in conditions like Hypersensitivity.

The severe or irreversible adverse effects of Clarithromycin, which give rise to further complications include Pseudomembranous colitis, Renal failure, Interstitial nephritis.Clarithromycin produces potentially life-threatening effects which include cerebial hemorrhage. which are responsible for the discontinuation of Clarithromycin therapy.The signs and symptoms that are produced after the acute overdosage of Clarithromycin include Hypokalemia, Hypoxia.The symptomatic adverse reactions produced by Clarithromycin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Vomiting, Diarrhea, Abdominal pain, Phlebitis, Glossitis, StomatitisX, Elevation of liver enzymes, Taste perversion, Increased intracranial pressure, Hypoglycemia.

Clarithromycin is primarily indicated in conditions like Chronic bronchitis, Metastatic germ cell cancer, Mycobacterial infection, Otitis media, Pharyngitis, Pneumonia, Respiratory tract infections, Rtis; otitis media, Sinusitis, Skin infections, Soft tissue infections, To counteract the folate-antagonist action of methotrexate, Tonsillitis, and can also be given in adjunctive therapy as an alternative drug of choice in Duodenal ulcer, Endocarditis.

Clarithromycin is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlprazolamArtesunateConcurrent use may increase artesunate serum concentrations. AstemizoleClarithromycin enhances the plasma concentration of astemizole by inhibiting CYP450 3A4 result inincreased plasma level may lead to prolongation of QT interval on the ECG, ventricular arrythmia, cardiac arrest and sudden death.MajorCoadministration is considered contraindicated. Loratadine, cetirizine, or fexofenadine are safer alternatives. Azithromycin and dirithromycin are appropriate alternatives of clarithromycin.CarbamazepineClarithromycin increses the serum concentration of carbamazepine by inhibiting its hepatic metabolism and decrease its clearance results in severe toxicity ModerateClosely monitor the plasma level of carbamazepine and carefully observed the signs of toxicity. Dose of carbamazipine should reduce if necessary.Cimetidine (HCl)CisaprideClarithromycin increases the plasma concentration of cisapride by inhibiting its metabolism result in prolongation of QT interval on ECG, ventricular arrythmia, cardiac arrest and death.MajorThis combination is considered contraindicated.conjugated Estrogens/Bazedoxifenemay increase the exposure of conjugated estrogensmonitr closelyCyclosporin ACyclosporin enhances the blood concentration of clarithromycin by inhibiting hepatic and intestinal metabolism result in increased risk of nephrotoxicity and neurotoxicity.ModerateCoadministration of these agents should be avoided. Blood level of cyclosporin and renal function should be checked frequently. Adjust the dose accordingly.Patient should notify their physician if experience nausea, vomiting, diarrhea, abdominal pain, dizziness, fatigue, or headache.DabrafenibStrong CYP3A4 inhibitors may increase levels of dabrafenibConsider alternate therapy.DigoxinClarithromycin increases the plasma concentration of digoxin by altering metabolism or absorption or by inhibiting renal secretion of digoxin.ModerateClosely monitor the serum level of digoxin. Patient should notify to physician if experience nausea, anorexia, visual disturbance, slow pulse or irregular heart beats.Dihydroergotamine (Mesylate)Clarithromycin increases the plasma concentration of dihydroergotamine by inhibiting hepatic metabolism.MajorCoadministration is considered contraindicated. Azithromycin is considered safer alternative of clarithromycin.DisopyramideClarithromycin increases the plasma concentration of disopyramide result in life-threatning malignant arrhythmia and prolong QT interval.MajorCoadministration should be avoided. Monitor the level of disopyramide.Ergotamine (Tartrate)Clarithromycin increases the plasma concentration of ergotamine by inhibiting hepatic metabolism.MajorCoadministration is considered contraindicated. Azithromycin is considered safer alternative of clarithromycin.ErlotinibThis CYP3A4 inhibitor increases levels/toxicity of erlotinibFluoxetine (HCl)Isosorbide (Dinitrate)Clarithromycin may decrease the metabolism of Isosorbide(Dinitrate). ModerateConsider an alternative drug in order to avoid toxicity of Isosorbide(Dinitrate). Some combinations are specifically contraindicated by manufacturers. Suggested dosage adjustments are also offered by some manufacturers. Please review applicable package inserts. Monitor for increased effects of Isosorbide(Dinitrate) if Clarithromycin is initiated/dose increased, and decreased effects if Clarithromycin is discontinued/dose decreased.LacosamideLoratadineClarithromycin increases the plasma concentration of loratadine by inhibiting its hepatic metabolism thus increases its plasma level upto 40%.MinorClosely monitor the patient for response and tolerance. Azithromycin and dirithromycin is considered as safer alternative.LorazepamLovastatinClarithromycin enhances the plasma concentration of lovastatin by inhibiting CYP450 3A4 results in severe myopathy.MajorTherapy should be stopped if level of creatinine kinase is increased or myopathy is diagnosed. Azithromycin and dirithromycin considered as safer alternatives of clarithromycin.MethylergonovineCoadministration with certain macrolide antibiotics may significantly increase the plasma concentrations of ergot derivatives.MajorGiven the potential for ergot toxicity characterized by peripheral vasospasm, ischemia, thrombosis, tachycardia and hypertension, concomitant use of ergot derivatives with clarithromycin, erythromycin, or troleandomycin is considered contraindicated. Although clinical data have not been reported, some manufacturers also consider the combination of cabergoline with macrolides contraindicated or to be avoided on theoretical grounds. Azithromycin may be a safer alternative during therapy with ergot derivatives.NelfinavirNevirapineNitrendipineMay increase the levels/effects of nitrendipineOmeprazoleomeperzole is used in combination with clarithromycin to treat patients with ulcer by helicobacter pylori.PantoprazoleConcurrent use may increase the risk of Pantoprazole side effects.Phenytoin (Na)Clarithromycin alters the clearence of phenytoin.MinorDuring coadministration caution is advised.PimozideClarithromycin increases the plasma concentration of pimozide by inhibiting its metabolism results inprolongation of QT interval, ventricular arrythmia, cardiac arrest and sudden death.MajorCoadministration is considered contraindicated.Azithromycin and dirithromycin is considered more safer alternative of clarithromycin.RabeprazoleCombined administration consisting of rabeprazole and clarithromycin resulted in increases in plasma concentrations of rabeprazole.RepaglinideClarithromycin increases repaglinide AUC by 40%.RifabutinRitonavirRitonavir increases the plasma concentration of clarithromycin by inhibiting CYP450 3A4, an enzyme responsible for metabolic conversion of clarithromycin to 14-hydroxyclarithromycin. ModerateDose of clarithromycin should be reduced upto 50% in patient with moderate renal impairment and upto 75% with severe renal impairment.SalmeterolConcurrent use may potentiate the risk of cardiovascular adverse events.SunitinibMay increases sunitinib concentrations.TacrolimusClarithromycin increases the serum concentration of tacrolimus by inhibiting CYP450 3A4-mediated hepatic metabolism results in increased toxicity.ModerateClosely monitor the plasma concentration of tacrolimus and renal function.Reduce the dose of tacrolimus if necessary. Azithromycin and dirithromycin is considered safer alternatives of clarithromycin.TerfenadineClarithromycin increases the plasma concentration of terfenadine by inhibiting CYP450 3A4-mediated first-pass metabolism result in high plasma level may be associated with prolongation of QT interval on the ECG, ventricular arrythmia, cardiac arrest and sudden death.MajorCoadministration is considered contraindicated. Loratadine, ctirizine, or fexofenadine is considered more safer than terfenadine and azithromycin and dirithromycin is consider more safer than clarithromycin.Theophyllinethe Cmax of theophylline increase upon repeated dose of clarithmycin Monitoring of Theophylline concentration during concomitant administration is recommendedVORICONAZOLE Voriconazole may increase the serum concentration of clarithromycin by decreasing its metabolismConsider alternate therapy or monitor for QTc prolongation , discontinued or dose changed.Warfarin (Na)Clarithromycin enhances the hypoprothrombinemic effect of warfarin by inhibiting its metabolismMajorFrequently check INR Adjust the dose of warfarin accordingly especially when start or discontinue therapy with clarithromycin.Patient should report any sign of bleeding to physician.ZidovudineClarithromycin alter the rate of absorption of zidovudine by changing gastric emptying time.MinorZiprasidoneConcomitant use of ziprasidone and clarithromycin increases the risk of QT prolongation. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Elevations of SGPT and SGOT Alkaline phosphatase levels are elevated.Serum creatinin raisedserum aspartate amino transferase, urinary catecholamine and 17- hydroxy corticosteroids

Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Oral Susp (reconstituted) Store at room temperature. Refrigeration and Freezing is not recommended. Protect from Sunlight. Use within 14 days if kept at room temperature. Tab Store in a well closed container, Below 40°C. Protect from Sunlight and Moisture.

Clarithromycin should be used with caution in patients with other illnesses or any allergy, especially allergies to drugs, arrythmias ,liver disease, jaundice (yellowing of the skin or eyes), kidney disease , or a history of colitis or stomach problems. This drug should be used only if clearly needed during pregnancy or lactation.