Cilazapril

Cilazapril is ACE inhibitor. ACE inhibitors prevent conversion of certain enzymes in the body and prevent constriction of blood vessels and lower the blood pressure and make the heart beat stronger. Cilazapril is used to treat hypertension (high blood pressure), heart failure and kidney disease in diabetic patients.

Brands
INHIBACE INHIBACE
Adult Dose
Dose: 1 to 2.5 mg
Single Dose: 1.8 (1.75)
Frequency: 24 hourly
Route: PO
Instructions: Max. 5 mg daily.
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
. It is of Synthetic origin and belongs to Diazepine Carboxylic Acid. It belongs to Angiotensin converting enzyme inhibitor-ACEI pharmacological group on the basis of mechanism of action and also classified in Antihypertensive Agents pharmacological group.The Molecular Weight of Cilazapril is 435.50. Its pKa is 6.4.
Contraindications
Cilazapril is contraindicated in conditions like Hypotension,Hypersensitivity,Ascites.
Effects
The severe or irreversible adverse effects of Cilazapril, which give rise to further complications include Angioneurotic edema.Cilazapril produces potentially life-threatening effects which include Hyperkalemia, Renal failure. which are responsible for the discontinuation of Cilazapril therapy.The signs and symptoms that are produced after the acute overdosage of Cilazapril include Prolonged hypotension.The symptomatic adverse reactions produced by Cilazapril are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Cough.
Indications
Cilazapril is primarily indicated in conditions like Essential hypertension, Gastric acid reduction during anaesthesia, Heart failure, Heart failure (adjunct), Hypertension.
Interactions
No data regarding the interactions of Cilazapril was found.
Interfrence
Renal vein blood sampling
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store in a well closed container, Below 25°C.
Warnings
Avoid cilazapril in patients with reno-vascular disease or aortic stenosis. It should be used with caution in patients with renal (kidney) impairment. Treatment should start under close medical supervision. Avoid use during pregnancy.
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