Cefpodoxime

Cefpodoxime is a third-generation broad spectrum β lactamase resistant cephalosporin antibiotic. Cephalosporins are derivatives of 7-aminocephalosporic acid and are closely related to penicillins in structure. Cephalosporins have a six membered sulfur containing ring adjoining a β lactam ring. Cefpodoxime is effective against a wide range of range of gram positive and gram negative bacteria. Administered orally. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Cefpodoxime (Proxetil) is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.


Adult Dose
Dose: 100 to 200 mg
Single Dose: 150 (150)
Frequency: 12 hourly
Route: PO
Instructions: Dose vary according to indication
Neonatal
Paedriatic
Dose: 4 mg/kg
Single Dose: 4 (4)
Frequency: 12 hourly
Route: Oral
Instructions:
Characteristics
Cefpodoxime (Proxetil) is the derivative of Cefpodoxime. It is of Semi Synthetic origin and belongs to Cephem Carboxylic Acid. It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Cephalosporin-3rd Gen pharmacological group.The Molecular Weight of Cefpodoxime is 557.60. Its pKa is 3.2.
Contraindications
Cefpodoxime is contraindicated in conditions like Hypersensitivity.
Effects
The severe or irreversible adverse effects of Cefpodoxime, which give rise to further complications include Thrombocytopenia, Hemolytic anemia, Hemolytic anemia, Stevens johnson syndrome, Stevens johnson syndrome, Eosinophilia, Eosinophilia, Hemolytic anemia, Anaphylactic shock, Acute liver injury, Purpuric nephritis, anaphylactic shock.Cefpodoxime produces potentially life-threatening effects which include Pseudomembranous colitis, Intravascular coagulation. which are responsible for the discontinuation of Cefpodoxime therapy.The signs and symptoms that are produced after the acute overdosage of Cefpodoxime include Diarrhea, Nausea & vomiting, Epigastric distress.The symptomatic adverse reactions produced by Cefpodoxime are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Fatigue, Vomiting, Anorexia, Diarrhea, Dyspnea, Chills, Urticaria, Glossitis, dizziness.
Indications
Cefpodoxime is primarily indicated in conditions like Benign gastric, duodenal or NSAID-associated ulceration, Gonorrhoea, Gynecological infections, Local infiltration, Lower respiratory tract infections, Otitis media, Sinusitis, Skin and soft tissue infections, Soft tissue and skin infections, Uncomplicated UTIs, Upper respiratory tract infections, Urinary tract infection.
Interactions
No data regarding the interactions of Cefpodoxime was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj (reconstituted soln) Store in refrigerator. Use within 14 days if kept at room temperature. Tab, Susp Store in a well closed container, at room temperature.
Warnings
Cefpodoxime should be used with caution in patients with impaired kidney or liver function. Appropriate measure should be taken if secondary infection occurs. It should be used with caution (if contains tartrazine) in patients with aspirin hypersensitivity, because it may cause allergic reactions (including bronchial asthma).
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