Cefpirome

Cefpirome is a fourth generation cephalosporin antibiotic. Cephalosporins are derivatives of 7-aminocephalosporic acid and are closely related to penicillins in structure. Cephalosporins have a six membered sulfur containing ring adjoining a β lactam ring. Cefpirome is effective in a large variety of bacterial infections, such as respiratory tract, ear, skin, septicaemia, infections in immunocompromized patients and urinary tract infections. Antibiotics require constant drug level in body for therapeutic effect.This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Cefpirome is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.

Brands
CEFROM CEFROM IVCEF IVCEF ROMICEF ROMICEF PIROME PIROME EFPIRO EFPIRO MORICEF MORICEF STERN STERN EFROME EFROME PIR PIR LORES LORES VALPIROM PRONA PRONA IPROME IPROME PIROXIQ CASCA CASCA PIROMECEF ORPAC PROMAK PROMAK PIROXIMAK ROSICEF ROSICEF
Adult Dose
Dose: 1 to 2 g
Single Dose: 1.5 (1.5)
Frequency: 12 hourly
Route: IV
Instructions:
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
Cefpirome Sulphate is the derivative of Cefpirome. It is of Semi Synthetic origin and belongs to Cephalosporin. It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Cephalosporin pharmacological group.The Molecular Weight of Cefpirome is 612.70.
Contraindications
Cefpirome is contraindicated in conditions like Hypersensitivity.
Effects
The severe or irreversible adverse effects of Cefpirome, which give rise to further complications include Thrombocytopenia, Hemolytic anemia, Hemolytic anemia, Granulocytopenia, Eosinophilia, Agranulocytosis, Eelvated hepatic enzymes, Superinfection.Cefpirome produces potentially life-threatening effects which include Anaphylaxis. which are responsible for the discontinuation of Cefpirome therapy.The symptomatic adverse reactions produced by Cefpirome are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Abdominal pain, Rashes, Urticaria, Pseudomembranous colitis, Increase in liver enzymes.
Indications
Cefpirome is primarily indicated in conditions like Bacteremia, Lower respiratory tract infections, Pneumonia, Promyelocytic leukemia, Septicaemia, Severe infections including bacteraemia and septicaemia and infections in neutropenic patients, Skin infections, Soft tissue infections, Urinary tract infection.
Interactions
No data regarding the interactions of Cefpirome was found.
Interfrence
Jaffe method for determining Creatinine
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Powder Store Below 25°C. Protect from Sunlight.
Warnings
Cefpirome should be used with caution in patients with impaired kidney or liver function. Appropriate measure should be taken if secondary infection occurs.
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