Cefepime

Cefepime is a fourth generation cephalosporin antibiotic. Cephalosporins are derivatives of 7-aminocephalosporic acid and are closely related to penicillins in structure. Cephalosporins have a six membered sulfur containing ring adjoining a β lactam ring. Cefepime is effective in a large variety of bacterial infections, such as respiratory tract, ear, skin and urinary tract infections. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Cefepime (HCl) is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.


Adult Dose
Dose: 1000 to 2000 mg
Single Dose: 1500 (1500)
Frequency: 12 hourly
Route: IV/IM
Instructions:
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
Cefepime (HCl) is the derivative of Cefepime. It is of Semi Synthetic origin and belongs to Cepheme Carboxylate. It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Cephalosporin-4th Gen pharmacological group.The Molecular Weight of Cefepime is 571.50.
Contraindications
Cefepime is contraindicated in conditions like Hypersensitivity to any component of product.
Effects
The severe or irreversible adverse effects of Cefepime, which give rise to further complications include Pseudomembranous colitis, Hemolytic anemia, Bone marrow depression, Cholestasis, Hemorrhage, Hypoprothorombinemia.Cefepime produces potentially life-threatening effects which include Seizures, Encephalopathy. which are responsible for the discontinuation of Cefepime therapy.The symptomatic adverse reactions produced by Cefepime are more or less tolerable and if they become severe, they can be treated symptomatically, these include Vomiting, Abdominal cramps, Renal failure, Oral candidiasis.
Indications
Cefepime is primarily indicated in conditions like Neutropenia, Pneumonia, Pyelonephritis, Skin infections, Urinary tract infection.
Interactions
No data regarding the interactions of Cefepime was found.
Interfrence
False +ve Direct Coombs Test False +ve Urinary Glucose Test (Clinitest)
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Dry Powder for Inj Store at room temperature, Below 25°C or in refrigerator. Do not Freeze. Protect from Sunlight. Inj (reconstituted Soln) Store at room temperature, Between 20°C-25°C or in refrigerator. Use within 7 days if refrigerated and within 24 hrs if kept at room temperature.
Warnings
Cefepime should be used with caution in patients with history of allergies, especially to penicillin, cephalosporins or any antibiotics, history of kidney disease, liver disease, seizure or colitis. It should be used with caution in the elderly patients, as kidney function is generally poor. It should be used with caution during pregnancy or lactation.
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