Carvedilol

Carvedilol is a non-selective β adrenoceptor blocking agent. Carvedilol is given as a racemic mixture. The S(-) isomer is a nonselective adrenoceptor blocking agent, but both S(-) and R(+) isomers have approximately equal a blocking potency. Carvedilol is used as a prophylaxis of stable angina and in the treatment of hypertension


Adult Dose
Dose: 12.5 mg
Single Dose: 12 (12.5)
Frequency: 24 hourly
Route: PO
Instructions: Initiallly.
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
. It is of Synthetic origin and belongs to Aminopropanol. It belongs to Alpha-Beta Blocker pharmacological group.The Molecular Weight of Carvedilol is 406.50. Its pKa is 7.9.
Contraindications
Carvedilol is contraindicated in conditions like Asthma,Cardiogenic shock,Hepatic dysfunction,Hypersensitivity.
Effects
The severe or irreversible adverse effects of Carvedilol, which give rise to further complications include Postural hypotension, Bronchospasm, Bradycardia.Carvedilol produces potentially life-threatening effects which include AV block. which are responsible for the discontinuation of Carvedilol therapy.The signs and symptoms that are produced after the acute overdosage of Carvedilol include Severe hypotension, Severe bradycardia.The symptomatic adverse reactions produced by Carvedilol are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Syncope.
Indications
Carvedilol is primarily indicated in conditions like Adjunct in heart failure, Angina, Angina pectoris, Cardiac arrhythmia, Cardiomyopathy, Congestive heart failure, Essential hypertension, Hypertension, Sedation for surgical and diagnostic proceduers, Sedation in intensive care, and can also be given in adjunctive therapy as an alternative drug of choice in Maintenance of anaesthesia, Myocardial infarction.
Interactions
Carvedilol is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAdrenalineAmiodarone (HCl)Clonidine (HCl)DigoxinDiminished cardiac contractile state.ModerateMonitor ECG for arrhythmias . The interaction may be more evident in children than adults.PropyliodoneConcurrent use may potentiate the risk of severe hypotensive or hypersensitivity reactions.ModeratePatients who have received beta-blockers should be closely monitored for adverse reactions to iodinated contrast media.RifampicinVerapamil (HCl) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Paediatrics, Cardiac / Hypertensive Patients, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store in a well closed container, Below 40°C. Protect from Sunlight and Moisture.
Warnings
Carvidilol should be used with caution in patients with medical history, including any allergies (especially drug allergies), history of severe heart failure, asthma, heart or blood vessel disease, kidney or liver disease, diabetes, hyperthyroidism, pheochromocytoma or Prinzmetals chest pain (angina). Use extreme caution if operating machinery or performing hazardous tasks because it may produce dizziness. Stand slowly to minimize the chance of dizziness or fainting. This medication should be used only when clearly needed during pregnancy. Carvidilol is not recommended during lactation. Caution is advised when this drug is used in the elderly patients.
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