Calcipotriol

'Calcipotriol is a synthetic analogue of vitamin D, a fat soluble sterol, sometimes considered to be hormone or hormone precursor. Calcipotriol is involved in promoting normal bone development in body by regulating calcium, phosphorus and minerals. Vitamin D is a secosteroid and sometimes popularly known as the ''sunshine vitamin'' because formed in the skin from 7-dehydrocholesterol under the influence of ultraviolet irradiation. Calcipotriol is also found in certain food. Fish liver oils, especially code liver oil are good sources of vitamin D. Calipotriol effects cell division and differentiation. At the cellular level the action of calcipotriol is very similar preparation for psoriosis to that of the natural hormones calcitriol or 1, 25 dihydroxy Vit D where or its systemic effects on Ca.'

Brands
DERVIT DERVIT-B DAIVONEX DAIVOBET CALCIBET CALCIPOT POTRIOL-B
Adult Dose
Dose: 0.01%
Single Dose: 0.005 (0.005)
Frequency: 12 hourly
Route: Topical
Instructions: -
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
Calcipotriol also known as Calcipotriene, Calcipotriene. . It is of Natural origin and belongs to Vitamin D3. It belongs to Dermatological Products and Antiposriasis pharmacological group.The Molecular Weight of Calcipotriol is 412.60. Its pKa is 15-29.
Contraindications
Calcipotriol is contraindicated in conditions like Known disorder of calcium metabolism.
Effects
The severe or irreversible adverse effects of Calcipotriol, which give rise to further complications include Photosensitivity, Hypercalcemia, Perioral dermatitis, Dry skin.The symptomatic adverse reactions produced by Calcipotriol are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Headache, Fatigue, Anorexia, Abdominal pain, Erythema, Weight LossX, Contact dermatitis, Hot flushes, Local irritation, Facial dermatitis, Xerosis, Contact dermatitis, Weakness.
Indications
Calcipotriol is primarily indicated in conditions like Psoriasis vulgaris, Scalp psoriasis.
Interactions
No data regarding the interactions of Calcipotriol was found.
Interfrence
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Oint Store in a well closed container, at room temperature, Below 25°C.
Warnings
Calcipotriol should be used with caution in elderly. It should not be used in patients with disorder of calcium metabolism and with a history of hypersensitivity reactions. Ointment should not be used on the face since the ointment formulation may give rise to irritation of the facial skin. Careful hand washing after use is recommended. It is classified as pregnancy category C should be used only when the benefit of therapy outweighs the risk to fetus. It should be used with caution in generalized pustular or erythrodermic exfoliative psoriasis.Avoid use in face and excessive exposure to sun light and sunlamps.
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