Bromazepam

Bromazepam is a benzodiazepine with general properties similar to those of diazepam. Bromazepam is used in the treatment of anxiety and as a hypnotic.


Adult Dose
Dose: 1.5 to 3 mg
Single Dose: 2.2 (2.25)
Frequency: 12 hourly
Route: PO
Instructions: For 8-12 Weeks. Frequency may increased to 3 times/day.
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
. It is of Synthetic origin and belongs to Benzodiazepine. It belongs to Chloride Channel Potentiater (GABA operated) pharmacological group on the basis of mechanism of action and also classified in Sedatives and Hypnotics and Benzodiazepine pharmacological group.The Molecular Weight of Bromazepam is 316.20.
Contraindications
Bromazepam is contraindicated in conditions like Hypersensitivity,Respiratory insufficiency,Hepatic insufficiency,Sleep apnea syndrome.
Effects
The severe or irreversible adverse effects of Bromazepam, which give rise to further complications include Psychosis.The symptomatic adverse reactions produced by Bromazepam are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Drowsiness, Fatigue, Irritability, Ataxia, Confusion, Hallucination, Muscle weakness, Nightmares, Agitation, Numbed emotions, Reduced alertness, Delusion.
Indications
Bromazepam is primarily indicated in conditions like Acute tension, Agitation, Anxiety, Bloating diarrohea, Dysmenorrhoea, Dyspnea, Epigastric pain, Hypertension, Hyperventilation, Insomnia, Irritable bladder, Irritable bowel syndrome, Pseudoangina pectoris, Spasm, Tachycardia.
Interactions
Bromazepam is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholCarbamazepineCimetidine (HCl)ErythromycinEthambutol (HCl)IprindoleTheoretical potential for BROMAZEPAM increasing the SEDATIVE effect of IPRINDOLE. MajorMay need to avoid combination.Iproniazid PhosphateInfrequent reports of BROMAZEPAM increasing the EXTRAPYRAMIDAL side effects of IPRONIAZID. ModerateIsoniazidMorphinePethidine (HCl)Phenytoin (Na)RifampicinSertindoleSertindole has the potential of causing drowsiness, thus in combination Bromazepam sedation may result. Terpin HydrateShould not use concurretly without doctors prescription.VORICONAZOLEvoriconazole may increase serum concentration o bromazepam by decreasing its metabolism.Monitor for changes in the therapeutic and adverse effects of bosentan if voriconazole is initiated, discontinued or dose changed. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Liver Malfunction, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tabs Store in a well closed container, Below 30°C. Protect from Sunlight.
Warnings
It should be used with caution in patients with respiratory disease, muscle weakness, history of drug or alcohol abuse, marked personality disorders, in pregnancy and breast feeding, reduce the dose in elderly and debilitated patients. Avoid prolonged use and abrupt withdrawal thereafter. It should be used with extreme caution in patients with renal and hepatic impairment. It should be injected intravenously slowly, not to be mixed with other solution.It is not recommended for use in depressive disorder,psychosis.
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