Azelaic Acid

Azelaic Acid is a straight chain saturated dicarboxylic acid occuring in rancid oleic acid. It has antibacterial and anti-inflammatory properties. It has cytotoxic effect on malignant or hyperactive melanocytes and has been administered topically and orally in the treatment of malignant melanoma, hyperpigmentation disorders and acne vulgaris.

Brands
SKINOREN AZELEXIN AZELEXIN AZELEXIN ACNESAFE AZECID ACNICAM ACNICAM ACNEGEN ACNEGEN AZECIL AZECIL EZIDERM EZIDERM
Adult Dose
Dose: 20%
Single Dose: 20 (20)
Frequency: 12 hourly
Route: Topical
Instructions: -
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
. It is of Semi Synthetic origin and belongs to Dicarboxylic Acid. It belongs to Dermatological Products pharmacological group.The Molecular Weight of Azelaic Acid is 188.20. Its pKa is 4.550.
Contraindications
Azelaic Acid is contraindicated in conditions like Hypersensitivity to the drug.
Effects
The symptomatic adverse reactions produced by Azelaic Acid are more or less tolerable and if they become severe, they can be treated symptomatically, these include Redness, Itching, Burning, Skin irritation, Contact dermatitis, Hypopigmentation, Dryness.
Indications
Azelaic Acid is primarily indicated in conditions like Acne vulgaris.
Interactions
No data regarding the interactions of Azelaic Acid was found.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Cream Store in a well closed container, Below 40°C. Do not Freeze.
Warnings
Azelaic acid should be used with caution in patients with any illness or any allergy. It should not applied to eyes, mouth or other mucous membrane. It is classified as pregnancy category B. This medication should be used with caution during pregnancy or lactation.
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