Atorvastatin

Atorvastatin is antihyperlipidemic agent. Atorvastatin is a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specifically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia. It prevents coronary atherosclerosis and reduces the risk of heart attack.


Brands
VASTOR-AM VASTOR-AM VASTOR VASTOR VASTOR WINSTOR WINSTOR WINSTOR AMLAT AMLAT AMLAT TROVAS TROVAS LIPIGAN LIPIGAN VASSODIP VASSODIP CORSAFE CORSAFE CORSAFE-AT CORSAFE-AT ORVA ORVA ORVA ORVA SENSICON SENSICON SENSICON PRO-STATIN PRO-STATIN PRO-STATIN LIPOTRIM LIPOTRIM LIPOTRIM VASCLEAR VASCLEAR ATOSTAT CALIPTROL CALIPTROL CALIPTROL COMBITROL COMBITROL ROVAX ROVAX E-STAT E-STAT RENORM RENORM AMTORIN PLUS AMTORIN AMTORIN ATOPITAR ATOPITAR ATOPITAR LIPIGET LIPIGET LIPIGET LIPIGET EZ CADWIN CADWIN LIPIREX LIPIREX LIPIREX AVOTIN CO-ATORAP CO-ATORAP CO-ATORAP CO-ATORAP ATOZET STAT A STAT A LIPIFAL LIPIFAL LIPIFAL AVAST AVAST GENOVAX GENOVAX GENOVAX GENOVAX TORSTAN TAVIST TAVIST TAVIST PLUS TAVIST PLUS TAVIST PLUS TAVIST PLUS TAVIST PLUS TAVIST PLUS CATRIL CATRIL CATRIL MEDILIP ROSTINOX ROSTINOX ASTAT ASTAT LIPIVASTIN LIPIVASTIN LIPIVASTIN AMSTATIN AMSTATIN AM DESCOL AM DESCOL AM DESCOL AM DESCOL AM DESCOL AM DESCOL AM DESCOL AM DESCOL DESCOL DESCOL DESCOL ATORSAN ATORSAN ATORVASTIN ATORVASTIN FOPSEC FOPSEC FOPSEC CHOLESTOR CHOLESTOR CHOLESTOR ATEASE ATEASE ATEASE ATEASE ATORLIP ATORLIP ATORVA ATORVA LIPITOR LIPITOR LIPITOR CADUET CADUET ASTATIN XTOR XTOR AZTOR EZ AVASCAR PLUS AVASCAR PLUS LIPISTAT LIPISTAT MINILIP MINILIP LOW VASE LOW VASE ATASTAN SNOLIP SNOLIP REDUSE REDUSE REDUSE ATRONIL ATRONIL ATRONIL ATRATA ATRATA SEMOSTATIN SEMOSTATIN SEMOSTATIN XETROL XETROL DELIP DELIP AMLOTIN AMLOTIN AMLOTIN LASTOLIP EZ LASTOLIP EZ LASTOLIP LASTOLIP LASTOLIP LASTOLIP CAPRISK COLEZAF COLEZAF ZEPITOR ZEPITOR SAVE SAVE SAVE SURVIVE-AT PLUS SURVIVE-AT PLUS MOMENTIUM MOMENTIUM MOMENTIUM MOMENTIUM-PLUS ETAR ETAR TORLIP 3H TORLIP 3H KOLMARK KOLMARK KOLMARK CARDISTATIN CARDISTATIN UNIVASTIN OSCAR OSCAR OSCAR ATORSCOT ATORSCOT ATORSCOT TAVAS TAVAS TAVAS STATOR LIPIDIP ERAVAS ATORIN ATORIN LOVA MEGAVASTIN MEGAVASTIN RIDLIP RIDLIP RIDLIP DEROT DEROT DEROT ATROLEAD ATROLEAD ATROLEAD COLSTAT COLSTAT HYPERSTATIN AV AV CHOLEIN CHOLEIN LIPVAS LIPVAS ATRACHOL ATRACHOL ASTRA ASTRA ZETAB-PLUS LIPIDIN LIPIDIN LIPIDIN LIPIDIN SAFEHEART SAFEHEART LYTRON LIPILOW LIPILOW LIPILOW ALTOLIP ALTOLIP ALTOLIP VOZAR VOZAR VOZAR ETORTIN LIPOTREX LIPICA PLUS LIPICA PLUS LIPICA PLUS LIPICA PLUS LIPICA PLUS LIPICA PLUS LIPICA PLUS LIPICA LIPICA LIPICA A-TIN ATOREX ATOREX A-VAST AMOSTATIN AMOSTATIN BVASTA BVASTA LIPAM LIPAM VASTA VASTA VASTA AMOSTIN AMOSTIN VASTAPINE VASTAPINE A-CHOLE A-CHOLE RAYTOR RAYTOR RAYTOR RATOR PLUS RATOR PLUS RATOR PLUS RATOR PLUS RATOR PLUS LOCHOL LOCHOL LOCHOL LOVAS
Adult Dose
Dose: 10 to 80 mg
Single Dose: 45 (45)
Frequency: 24 hourly
Route: PO
Instructions:
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions:
Characteristics
Atorvastatin Calcium is the derivative of Atorvastatin. It is of Synthetic origin and belongs to Pheynylcarbomoyli. It belongs to HMGCoA reductase inhibitor pharmacological group on the basis of mechanism of action and also classified in Antilipemic Agent pharmacological group.The Molecular Weight of Atorvastatin is 1208.42. Its pKa is 4.6.
Contraindications
Atorvastatin is contraindicated in conditions like Hypersensitivity,Pregnancy,Breast feeding,Actinic keratosis.
Effects
The symptomatic adverse reactions produced by Atorvastatin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Weakness, Headache, Diarrhea, Fever, Myalgia, Constipation, Insomnia, Abdominal pain, Skin rashes, Blurred vision, Pharyngitis, Dyspepsia, Malaise, Asthenia, Arthralgia, Elevation of liver enzymes, Myopathy, Backache, Increased intracranial pressure, GI disturbance, Sinusitis.
Indications
Atorvastatin is primarily indicated in conditions like Familial hypercholesterolaemia, Homozygous familial hypercholesterolemia, Hypercholesterolaemia, Hyperlipoproteinaemia, Hypertriglyceridaemia, NSAID-associated gastric and duodenal ulcers and duodenal errosions.
Interactions
Atorvastatin is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAliskirenAmprenavirAmprenavir possibly increases plasma concentration of Atorvastatin. ADVICE: Avoid concomitant use. MajorCimetidine (HCl)Cimetidine may decrease the metabolism of Atorvastatin. ModeratePatients who require concomitant thaerapy should be monitored for altered antihypertensive response if Cimetidine is introduced or discontinued, or when its dosage is modified.Colestipol (HCl)Cyclosporin ACyclosporin may increase the serum concentration of Atorvastatin. MajorMonitor altered effects (eg, increased serum CPK, myopathy, rhabdomyolysis) of Atorvastatin if Cyclosporin is introduced or discontinued, or when its dosage is modified.DigoxinAtorvastatin possibly increases plasma concentration of Digoxin.ErythromycinErythromycin may decrease the metabolism, via CYP isoenzymes, of Atorvastatin. Possible increased risk of myopathy when atorvastatin given with erythromycin.ModerateWhen coadministration of a Macrolide antibiotic and an HMG-CoA reductase inhibitor is necessary, consider using a combination which appears to hold the lowest risk for the development of rhabdomyolysis. Azithromycin, Dirithromycin, and Spiramycin can probably be used safely (ie, no increased risk of side effects) with any HMG-CoA reductase inhibitor. Neither Fluvastatin, Pravastatin, nor Rosuvastatin would likely be affected by Macrolides.Mibefradil (Di HCl)Nicotinic AcidIncreased risk of myopathy when statin (e.g Atorvastatin) given with nicotinic acid (applies to lipid regulating doses of nicotinic acid.RepaglinideAtorvastatin may increase repaglinide concentrations by decreasing metabolism. Warfarin (Na)Atorvastatin may enhance the anticoagulant effect of Warfarin. Moderate (Sequence important)Patients who require concomitant thaerapy should be monitored for altered response whenever Warfarin is introduced or discontinued, or when its dosage is modified. Dosage adjustments of Warfarin may be needed. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store in a well closed container, Between 20°C-25°C. Protect from Moisture and Heat.
Warnings
Atrovastatin should be used with caution in patients with liver disease, severe infection, heart disease, thyroid problems, uncontrolled seizures, recent major surgery, low blood pressure, any allergy or any other medical problem. Atrovastatin may cause dizziness or lightheadedness, so patient should observe caution while driving or engaging in activities requiring alertness. Atorvastatin should not be used during pregnancy or lactation.
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