Benoxaprofen

Benoxaprofen is NSAID structurall yrelated to ibuprofen. It was formerly used in rheumatoid arthritis and osteoarthritis. But due to severe side-effects, it ahs been withdrawn from the market.


Brands
Adult Dose
Dose: 4.28 mg/kg
Single Dose: 4.3 (4.28)
Frequency: 12 hourly
Route: PO
Instructions: -
Neonatal
Dose: Not used in this age group
Single Dose:
Frequency:
Route:
Instructions:
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
. It is of Synthetic origin and belongs to Proprionic Acid. It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action and also classified in Analgesics and Anti-inflammatory Agents pharmacological group.The Molecular Weight of Benoxaprofen is 301.70. Its pKa is 3.5.
Contraindications
Benoxaprofen is contraindicated in conditions like Peptic ulcer,Renal diseases,Liver diseases.
Effects
The severe or irreversible adverse effects of Benoxaprofen, which give rise to further complications include Stevens johnson syndrome, Epidermal necrolysis.Benoxaprofen produces potentially life-threatening effects which include Obstructive Jaundice. which are responsible for the discontinuation of Benoxaprofen therapy.The symptomatic adverse reactions produced by Benoxaprofen are more or less tolerable and if they become severe, they can be treated symptomatically, these include Photosensitivity, Redness, Itching, Burning, Subepidermal cysts.
Indications
Benoxaprofen is primarily indicated in conditions like Osteoarthritis, Rheumatoid arthritis, Soft tissue disorders.
Interactions
No data regarding the interactions of Benoxaprofen was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab
Warnings
Donot use on broken or secondarly infected skin, during pregnancy and breast feeding. Not to apply in face, prevent contact with eyes.
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