Sulbactam

Sulbactam is a beta lactamase inhibitor. It does not have significant antibacterial activity, rather it binds and inactivates β- lactamases (the family of enzymes hydrolyzes the cyclic amide bond of β-lactam ring, which result in loss of bactericidal activity), thereby protecting antibiotics that are normally the substrates of these enzymes. Sulbactam is used with penicillins and other β-lactam antibiotics to protect them from enzymatic inactivation.


Brands
UNASYN UNASYN UNASYN UNASYN UNASYN SULBAMOX INFANTA SULZON SULZON SULBAMOX SULBAMOX SULBAMOX SULBAMOX SULBARAX SULBARAX SULBARAX PARATAM PARATAM MOXSUL MOXSUL TOXIRID TOXIRID TOXIRID CEBAC CEBAC CEFACTUM CEFACTUM CEFOSUB EZONE EZONE PARABAC PARABAC ACTUM ACTUM BIPED BIPED ELEVA PLUS ELEVA PLUS SULPAZONE BACTECEF BACTECEF JOOP JOOP INJECTAZONE PLUS INJECTAZONE PLUS ELIZONE ELIZONE ZAM FOPERA FOPERA PSULB PSULB ZINIMIN ZINIMIN ZINIMIN CEFBRO CEFBRO CEBACTUM CEBACTUM BACTAMOX PLUS BACTAMOX PLUS BACTAMOX PLUS CEF-NA SULBAXON SULBAXON WINBACT WINBACT CEFPEC CEFPEC COMBICIN CEFPRAN CEFPRAN CEFOPEARL CEFOPEARL UNIBACTUM UNIBACTUM GREENEC GREENEC SULPERAZONE SULPERAZONE DEACT DEACT ADZONE ADZONE FORZON FORZON LECFOBAC LECFOBAC NEOBACT NEOBACT SULKAM FORTE SULKAM FORTE ARASALZONE ARASALZONE ASTELABECT ASTELABECT AZOSUL AZOSUL BACTICEF BACTUM BACTUM BRIXUL BRIXUL CEFSUL CEFSUL CEFSUL IMZONE IMZONE L-BACTAM L-BACTAM LINZONE LINZONE MECTRUM MECTRUM SALAR SALAR SEBACTUM SEBACTUM SULBRON SULBRON SULGEN SULGEN USZONE USZONE ZONDEX ZONDEX ZONESUL ZONESUL AIMPRAZONE AIMPRAZONE AMBAC AMBAC CEFOPAR CEFOPAR CERA CERA MONOBACT MONOBACT EBACTUM MAXONIL MAXONIL MEGAROZE MEGAROZE MIZIO NOVOCEF NOVOCEF SULBACEF PLUS SULBACEF PLUS SULPAZONE D SULPRON SULPRON VALBACTUM VALBACTUM VALBACTUM WISEBACT WISEBACT MUTACEF MUTACEF PERASURE PERASURE SOPRA INJECTION OBSAL OBSAL SUZONE SUZONE 2SUM 2SUM CEFEXTRA CEFEXTRA GILTUM GILTUM OPI SAL OPI SAL Q-BACT Q-BACT RAZOBACT RYTICEF PLUS RYTICEF PLUS SULCEF SULCEF SULCEFTA SULCEFTA SULZEB SULZEB AMPITAM CEF + CEF + CEFRASUL CEFRASUL EFABEC EFABEC PAROAT PAROAT PHARSUL PHARSUL QIN-BACT QIN-BACT SACTUM SACTUM SUFZON SUFZON FUTAZIM GILAXIM GILAXIM GILAXIM
Adult Dose
Dose: 250 mg
Single Dose: 250 (250)
Frequency: 6 hourly
Route: PO/IV/IM
Instructions: In combination with Amoxycillin 250mg
Neonatal
Dose: 25 mg/kg
Single Dose: 25 (25)
Frequency: 12 hourly
Route: Intavenous
Instructions: For 5---14 days
Paedriatic
Dose: 16.66 mg/kg
Single Dose: 17 (16.66)
Frequency: 8 hourly
Route: Intramuscular
Instructions: For 5---14 days
Characteristics
Sulbactum Trihydrate, Sulbactum Trihydrate are the derivatives of Sulbactam. It is of Synthetic origin and belongs to Penicillanic acid sulphone. It belongs to Antibacterial pharmacological group.The Molecular Weight of Sulbactam is 233.20.
Contraindications
Sulbactam is contraindicated in conditions like Hypersensitivity.
Effects
The severe or irreversible adverse effects of Sulbactam, which give rise to further complications include Exfoliative dermatitis, Bone marrow depression.Sulbactam produces potentially life-threatening effects which include Anaphylaxis. which are responsible for the discontinuation of Sulbactam therapy.The signs and symptoms that are produced after the acute overdosage of Sulbactam include Seizures.The symptomatic adverse reactions produced by Sulbactam are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Fatigue, Abdominal pain, Dysuria, Malaise, Glossitis, Urinary RetentionX, Epistaxis, Urinary retention.
Indications
Sulbactam is primarily indicated in conditions like Beta lactamase resistant pseudomonas, Gynecological infections, Intra-abdominal infections, Methicillin resistant staphylococci, Skin infections.
Interactions
No data regarding the interactions of Sulbactam was found.
Interfrence
False +ve Test for Urinary Aminoacids
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store Below 40°C. Protect from Sunlight.
Warnings
Sulbactam should be used with caution in patients with illnesses or any allergy especially to penicillin or other antibiotics. In diabetic patients, this can affect the results of clinitest tablets. This may interfere with oral contraceptives, if using oral contraceptives discuss with doctor alternate birth control methods to use, while using this medication. It should be used only if clearly needed during pregnancy or lactation.
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