Amisulpride

Amisulpride is oral anti-psychotic drug that acts by blocking presynaptic (in low doses) and postsynaptic (at high doses) dopamine receptors (D2 and D3). Amisulpride is used to control symptoms of schizophrenia. (a severe mental disorder associated with brain abnormalities and particularly evidenced by disorganized speech and behavior, elusions, and hallucinations).

Brands
SOLIAN SOLIAN SOLIAN SOLIAN SOLIUM SOLIUM
Adult Dose
Dose: 0.714 to 4.285 mg/kg
Single Dose: 2.5 (2.4995)
Frequency: 24 hourly
Route: PO
Instructions: -
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Benzamide. It belongs to Sedatives and Hypnotics pharmacological group.The Molecular Weight of Amisulpride is 369.50.
Contraindications
Amisulpride is contraindicated in conditions like Phaeochromocytoma,Hypomania,Porphyria.
Effects
The signs and symptoms that are produced after the acute overdosage of Amisulpride include Tachycardia, Convulsions, Coma, Restlessness.The symptomatic adverse reactions produced by Amisulpride are more or less tolerable and if they become severe, they can be treated symptomatically, these include Sleep disturbance, Agitation, Overstimulation.
Indications
'Amisulpride is primarily indicated in conditions like Anxiety, Control of muscarinic side-effects of neostigmine, Depression, Peptic ulcer, Schizophrenia, Schizophrenia (acute psychotic episode), Schizophrenia (predominantly negative symptoms), Tourette''s syndrome, Vertigo.'
Interactions
No data regarding the interactions of Amisulpride was found.
Interfrence
Risks
Drug should not be given to Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store in a well closed container, Below 25°C.
Warnings
Atypical antipsychotics (e.g Amisulpride) should be used with caution in patients with cardiovascular disease, or a history of epilepsy; it should be used with caution inelderly; while atypical antipsychotics (e.g Amisulpride) have not generally been associated with clinically significant prolongation of the QT interval, they should be used with care if prescribed with other drugs that increase QT interval. DRIVING: Drowsiness may affect performance of skilled tasks (e.g driving or operating machinery), especially at start of treatment; effects of alcohol are enhanced. WITHDRAWL: Withdrawl of antipsychotic drugs after long-term therapy should always be gradual and closely monitored to avoid the risk of acute withdrawl syndrome or rapid relapse.
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