Aminophylline

Aminophylline is a theophylline ethylenediamine complex. Aminophylline is the salt of theophylline most commonly used for therapeutic purposes. It contains 86% theophylline by weight. It acts as a bronchodialator (dilates the bronchi i.e. air passage). It improves breathing by opening air passages in the lungs.


Adult Dose
Dose: 0.5 mg/ kg/hr
Single Dose: 0.5 (0.5)
Frequency: As recommended.
Route: IV Inf
Instructions: Maintenance dose.
Neonatal
Dose: 0.2 mg/kg/hr
Single Dose: 0.2 (0.2)
Frequency: As recommended.
Route: Infusion
Instructions: Maintenance for 24 hrs or as required
Paedriatic
Dose: 1 to 1.2 mg/kg.hr
Single Dose: 1.1 (1.1)
Frequency: As recommended.
Route: IV Infusion
Instructions: Maintenance for 24 hours or As Required
Characteristics
Aminophylline also known as Metaphylline, Metaphylline. Aminophylline Hydrate is the derivative of Aminophylline. It is of Synthetic origin and belongs to Xanthine. It belongs to Phosphodiesterase inhibitor pharmacological group on the basis of mechanism of action and also classified in Bronchodilator pharmacological group.The Molecular Weight of Aminophylline is 420.40.
Contraindications
Aminophylline is contraindicated in conditions like Alcohol dependence,Hyperthyroidism,Peptic ulcer,Febrile illness.
Effects
The severe or irreversible adverse effects of Aminophylline, which give rise to further complications include Withdrawal symptoms.Aminophylline produces potentially life-threatening effects which include Convulsions, Hypoglycemia, Hypovolemia. which are responsible for the discontinuation of Aminophylline therapy.The signs and symptoms that are produced after the acute overdosage of Aminophylline include Convulsions, Hypokalemia.The symptomatic adverse reactions produced by Aminophylline are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Diarrhea, Anxiety, Restlessness, Palpitation, Tachycardia, Tremors, Insomnia, Abdominal pain, Urinary retensionX, Nausea and vomiting.
Indications
Aminophylline is primarily indicated in conditions like Acute severe asthma, Asthma, Obstructive airway disease, Reversible airways obstruction.
Interactions
Aminophylline is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAllopurinolAscorbic AcidCimetidine (HCl)DisulfiramFluvoxamine (Maleate)HalothaneHalothaneHydroxyprogesteroneInterferon AlphaInterferon Alpha 2aKetamine (HCl)MetipranololTheoretical potential for METIPRANOLOL [EYE] reducing the BRONCHODILATOR effect of AMINOPHYLLINE. MetrizamideIntrathecal administration of iodinated contrast media may induce seizures. Although clinical data are generally lacking, there may be a theoretical risk of increased seizureMajorDrugs that can lower the seizure threshold should preferably be withheld for at least 48 hours prior to and 24 hours following intrathecal administration of iodinated contrast media, provided that temporary interruption of therapy does not pose an undue risk to the patient. Otherwise, close monitoring is advised during and after contrast administration.Obidoxime (Cl)PralidoximePromethazine (HCl)RifampicinSalmeterolConcurrent use may potentiate the risk of adverse effects.SulphinpyrazoneThiabendazole These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Cardiac / Hypertensive Patients, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Liq Store in a well closed container, Below 40°C. Do not Freeze. Protect from Sunlight and Moisture. Suppositories Store in a well closed container. Do not Freeze. Protect from Sunlight and Moisture. Tab, Inj Store in a well closed container, Below 40°C. Protect from Sunlight and Moisture.
Warnings
Aminophylline should be used with caution in patients with severe heart, kidney, liver diseases, hyperthyroidism, congestive heart failure (CHF) or peptic ulcer. It should be used with caution in neonates and in elderly persons.
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