AXAL AXAL AXAL ALPRAM PINIX PINIX PINIX XYLEPAM LAPRANX LAPRANX LAPRANX ALPAX ALPAX ANPRA ANPRA ANPRA ANRID ANRID ZENITH ZENITH ZENITH XOLAM SR XOLAM SR XOLAM SR ALORAM ALORAM ALORAM ALORAM PRAZ PRAZ PRAZ ALP ALP ALP SHENLAX ROSAM NERAM LAMZO LAMZO LAMZO Z-NEST HILAXIN HILAXIN ENZO ENZO ENZO ANXIORID ANXIORID ANXIORID ALPRAZOTA MAZOLAM MAZOLAM MAZOLAM AZOLAM AZOLAM AZOLAM XANAX XANAX XANAX AZOLEX AZOLEX PROZAM NOXALAM MULIS MULIS MULIS ANXNIL ZOLAM ZOLAM ZOLAM ALPROX NEUXAM NEUXAM NEUXAM LYDIA LYDIA SYMS SYMS NERVIN NERVIN NERVIN ANXOTEN ONAX ONAX ONAX LAMPRO LAMPRO VALOZAM VALOZAM VALOZAM ALPRANAX ALPRANAX BIZOLAM BIZOLAM BIZOLAM LEAZAM LEAZAM LEAZAM SYNPRAM PROLAM PRAZODAN PRAZODAN PRAZODAN RAZLAM RAZLAM RAZLAM PRANAX PRAZOLAM PRAZOLAM PRAZOLAM ZOLGRAY ZOLGRAY ZOLGRAY ZOLGRAY M-ZOLAM NIZAM NIZAM NIZAM ALPAMED ALPAMED ALPAMED

Dose: 0.25 to 0.5 mg
Single Dose: 0.38 (0.375)
Frequency: 8 hourly
Route: PO
Instructions: Max. 3mg/day

Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group

Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group

. It is of Synthetic origin and belongs to Benzodiazepine. It belongs to Chloride Channel Potentiater (GABA operated) pharmacological group on the basis of mechanism of action and also classified in Psychotherapeutic Drugs and Benzodiazepine pharmacological group.The Molecular Weight of Alprazolam is 308.80. Its pKa is 2.4.

Alprazolam is contraindicated in conditions like Pulmonary insufficiency,Narrow-angle glaucoma,Hypersensitivity.

Alprazolam produces potentially life-threatening effects which include Respiratory depression, Blood dyscrasias. which are responsible for the discontinuation of Alprazolam therapy.The signs and symptoms that are produced after the acute overdosage of Alprazolam include Coma, Drowsiness, Confusion, Ataxia, Excitation, Sedation, CNS depression.The symptomatic adverse reactions produced by Alprazolam are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Drowsiness, Fatigue, Excitement, Ataxia, Anxiety, Insomnia, Confusion, Pain, VertigoX, Sedation, Hallucination, Depression, Somnolence, Muscle weakness, Thrombophlebitis, Changes in libido, GI disturbance, Tension, Trembling, Withdrwal seizures, Rage.

Alprazolam is primarily indicated in conditions like Anxiety, Panic disorders, Premenstural syndrome, and can also be given in adjunctive therapy as an alternative drug of choice in Depression.

Alprazolam is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholAlcohol reduces the clearance of alprazolamAmprenavirIncreased risk of prolonged sedation and respiratory depression when Amprenavir given with Alprazolam.AntazolineIncreased antimuscarinic and sedative effects when antihistamines (e.g Antazoline) given with anxiolytics (e.g Alprazolam).Cimetidine (HCl)ClarithromycinClozapinecyclobenzaprine hydrochlorideCentral nervous system- and/or respiratory-depressant effects may be additively or synergistically increased.MajorDuring concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression.DiflunisalDigoxinAlprazolam may increase the serum concentration of digoxin. ADVICE: Avoid concomitant use.ModerateNo action required.Diltiazem (HCl)DisulfiramErythromycinErythromycin reduces the clearance of alprazolamFluconazoleFluoxetine (HCl)Fluoxetine reduces the clearance of alprazolamFluvoxamine (Maleate)Imipramine (HCl)The steady state plasma concentrationis increased by AlprazolamIprindoleTheoretical potential for ALPRAZOLAM increasing the SEDATIVE effect of IPRINDOLE. ModerateMay need to avoid combination.Iproniazid PhosphateInfrequent reports of ALPRAZOLAM increasing the EXTRAPYRAMIDAL side effects of IPRONIAZID.ModerateIsoniazidItraconazoleKetoconazoleLabetalolLevodopaLofepramine (HCl)Theoretical potential for ALPRAZOLAM increasing the SEDATIVE effect of LOFEPRAMINE. ModerateMay need to avoid combinationMetoprolol (Tartrate)MetronidazoleMiconazole (Nitrate)OmeprazoleParegoricCentral nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients.ModerateDuring concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Ambulatory patients should be made aware of the possibility of additive CNS effects (e.g., drowsiness, dizziness, lightheadedness, confusion) and counseled to avoid activities requiring mental alertness until they know how these agents affect them. Patients should also be advised to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.Phenytoin (Na)PropoxypheneSilymarinSilymarin may interfere with Alprazolam because both drugs are broken down by the same liver enzymes.VORICONAZOLEVoriconazole may increase the serum concentration by decreasing its metabolism.Monitor for alprazolam toxicity if voriconazole is initiated or dose increased. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Store in a well closed container. Protect from Sunlight. Tab Store Between 15°C-25°C. Protect from Sunlight, Moisture and Heat.

Perform periodic blood counts and liver function tests during long term therapy. Alprazolam should be used with caution in patients, if increased salivation cause respiratory difficulty, because it may produce an increase in salivation. Give least amount of drug to patients in whom depression accompanies anxiety and suicidal tendencies may be present. Use with caution (if it contains tartrazine) in patients with aspirin hypersensitivity because it may cause allergic reaction (including bronchial asthma).