XATRAL-LP XATRAL XATRAL EZIFLO XL EZIFLO SR FUZIN KHLOCK XR KHLOCK ZATRAL ZATRAL XR ALFUPROZIN

Dose: 2.5 to 10 mg
Single Dose: 6.2 (6.25)
Frequency: 8 hourly
Route: PO
Instructions:

Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group

Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group

. It is of Synthetic origin and belongs to Furancarboxamide. It belongs to Alpha-1 adrenergic antagonist pharmacological group on the basis of mechanism of action and also classified in Selective 5-HT3 Receptor Antagonist pharmacological group.The Molecular Weight of Alfuzosin is 425.90. Its pKa is 8.13.

Alfuzosin is contraindicated in conditions like Hypotension,Hypersensitivity,Hepatic insufficiency.

The symptomatic adverse reactions produced by Alfuzosin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Vertigo, Headache, Nausea, Vomiting, Tachycardia, Skin rash, Postural hypotension, Syncope, dizziness.

Alfuzosin is primarily indicated in conditions like Benign prostatic hyperplasia, and can also be given in adjunctive therapy as an alternative drug of choice in Hypertension.

Alfuzosin is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAtenololEnhanced hypotensive effects when alpha-blockers (e.g Alfuzosin) given with beta-blockers (e.g Atenolol).MajorHalothaneEnhanced hypotensive effects when alpha-blockers (e.g Alfuzosin) given with general anesthetics (e.g Halothane)MajorMoxisylytePossible severe postural hypotension when alpha-blockers (e.g Alfuzosin) given with moxisylyte.MajorVORICONAZOLEVoriconazole may increase the serum concentration of alfuzosin by decreasing its metabolismUse of alfuzosin with strong CYP3A4 inhibitors is contraindicated These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Tab Store in a well closed container, at room temperature, Below 30°C. Protect from Moisture.

To avoid first dose effect i.e. marked postural hypotension and syncope, initial dose should be reduced and to be taken at the bed time.