Acitretin

Acitretin is orally absorbed retinoid. Acitretin is made by chemical synthesis. Acitretin is effective in the treatment of severe psoriasis and other serious disorders of skin growth.


Adult Dose
Dose: 25 to 75 mg
Single Dose: 50 (50)
Frequency: 8 hourly
Route: PO
Instructions: For 2-4 weeks.
Neonatal
Paedriatic
Dose: 500 ug/kg
Single Dose: 500 (500)
Frequency: 24 hourly
Route: Oral
Instructions: -
Characteristics
. It is of Synthetic origin and belongs to Tetraenoic Acid. It belongs to Dermatological Products and Antiposriasis Oral pharmacological group.The Molecular Weight of Acitretin is 326.40. Its pKa is 5.
Contraindications
Acitretin is contraindicated in conditions like Depression,Diabetes mellitus,Hyperlipidemia,Hypervitaminosis.
Effects
The severe or irreversible adverse effects of Acitretin, which give rise to further complications include Seizures, Osteoporosis, Exostosis, Corneal opacity, Skeletal hyperostoses.The signs and symptoms that are produced after the acute overdosage of Acitretin include Hepatic enzyme disturbance, Erythema.The symptomatic adverse reactions produced by Acitretin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Alopecia, Myalgia, Pruritus, Erythema, Dryness of mouth, Depression, Arthralgia, Fragility of skin, Cheilitis, Conjunctivitis, Sore throat, Vasculitis, Voice disturbance, Elevated SGPT & SGOT, Epistaxis, Elevated serum triglyceride.
Indications
Acitretin is primarily indicated in conditions like Congenital ichthyosis, Dariers disease, Psoriasis, and can also be given in adjunctive therapy as an alternative drug of choice in Dermatosis, Discoid lupus erythematosus, Granuloma annulare.
Interactions
Acitretin is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementRetinol (Vitamin A) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Caps Store in a well closed container, Below 40°C. Protect from Sunlight and Heat.
Warnings
Use with caution in patients with kidney disease, liver disease, heart disease, diabetes or if have any drug allergies. It is recommended that persons taking this medication should not donating blood for at least three years after stopping therapy. This medication increases sensitivity to the sun, so wear protective clothing and use a sunscreen before exposure to UV or sunlight. Avoid drinking alcohol while taking this medication and for two months after stopping the drug. This drug should not be used during pregnancy and lactation.
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