Bendrofluazide

Bendrofluazide is a diuretic. Bendrofluazide is used in hypertention to lower the high blood pressure. It increases urination and is used to treat fluid overload (abnormal accumulation of fliuid in body cavities, tissue etc). It acts by reducing sodium reabsorption in the kidney. Less potent than frusemide and mersalyl but has longer action. Bendrofluazide is effective orally.


Brands
Adult Dose
Dose: 0.03 to 0.285 mg/kg
Single Dose: 0.16 (0.1575)
Frequency: 24 hourly
Route: PO
Instructions: -
Neonatal
Dose: 0.1 to 0.2 mg/kg
Single Dose: 0.15 (0.15)
Frequency: 24 hourly
Route: oral
Instructions:
Paedriatic
Dose: 0.1 to 0.2 mg/kg
Single Dose: 0.15 (0.15)
Frequency: 24 hourly
Route: Oral
Instructions: -
Characteristics
Bendrofluazide also known as Bendroflumethiazide. . It is of Synthetic origin and belongs to Sulphonamide. It belongs to NaCl cotransport inhibitor pharmacological group on the basis of mechanism of action and also classified in Diuretic Thiazide pharmacological group.The Molecular Weight of Bendrofluazide is 421.40. Its pKa is 8.5.
Contraindications
Bendrofluazide is contraindicated in conditions like Diabetes mellitus,Renal failure,Hypokalaemia,Hypersensitivity.
Effects
The severe or irreversible adverse effects of Bendrofluazide, which give rise to further complications include Thrombocytopenia, Cholestatic jaundice, Aplastic anemia, Hemolytic anemia, Photosensitivity, Necrotizing vasculitis, Acute interstitial pulmonary edema, Skin rashes.Bendrofluazide produces potentially life-threatening effects which include Hyponatremia, Hypokalemia, Cardiac arrhythmias, Abnormal lipid profile. which are responsible for the discontinuation of Bendrofluazide therapy.The signs and symptoms that are produced after the acute overdosage of Bendrofluazide include Hypotension, Volume depletion, Hypokalemia, Hyponatremia.The symptomatic adverse reactions produced by Bendrofluazide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Gout, Impotence.
Indications
Bendrofluazide is primarily indicated in conditions like Diabetes insipidus, Disorders of calcium balance, Heart failure, Hypertension, Oedema, Peripheral edema.
Interactions
Bendrofluazide is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholAlcuronium (Cl)AllopurinolAmphotericin BAstemizoleBumetanideCarbenoxolone (Na)CholestyramineColestipol (HCl)DigoxinHalofantrine (HCl)LithiumPancuronium (Br)PimozideProbenecidQuinidineRitodrine (HCl)Sotalol (HCl)TerbutalineTerfenadineTrimethoprimTubocurarine (Cl) Warfarin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Apparent polycythemia with an elevated hematocrit
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store in a well closed container, Below 40°C.
Warnings
Bendrofluazide should be used with caution in patients with diabetes, kidney or liver disease or any drug allergy. Caution must be observed when eating large amounts of food high in potassium such as bananas, baked potatoes, raisins, cooked spinach and other foods. Alcoholic beverages may increase the effects of this drug, causing dizziness or lightheadedness, so limit alcohol intake. Use caution while engaging in activities requiring alertness. This drug changes fluid balance, cause dizziness, if change from a lying to a standing position too rapidly, avoid this by sitting up a few minutes before rising. It should be used with caution during pregnancy or lactation.
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